Professor Sian HensonProfessor in ImmunologyCentre: Translational Medicine & TherapeuticsEmail: s.henson@qmul.ac.uk Telephone: +44(0) 20 7882 2100Twitter: @DrSianHProfileResearchPublicationsSponsorsCollaboratorsProfileORCID iD: 0000-0003-1893-4912 Sian Henson obtained her PhD at Imperial College London in 2000. Subsequently, Sian undertook postdoctoral training with Prof Richard Aspinall at Imperial College investigating the role of IL-7 in thymic atrophy. She then moved to Prof Arne Akbar’s lab at University College London where she directed her focus towards understanding the role of inhibitory receptors during ageing and found that senescence is not passive end-stage processes but is controlled by active signalling pathways. More recently she has become interested in the metabolic requirements of primary human senescent T cells. Sian became a lecturer at the William Harvey Research Institute in 2015 where she has established her own research group investigating the deregulation of T cell metabolism during human ageing and how it maintains an inflammatory deleterious state. Professor Henson serves as a committee member for the BBSRC and the Dunhill Medical Trust. She is the Chair of the British Society of Immunology affinity group for Immune senescence. Sian is also an Associate Editor for Frontiers of Immunology. Current academic roles include module lead for Immunology for the Biomedical Sciences BSc.ResearchGroup members Johannes Schroth Conor Garrod-Ketchley Summary Ageing is accompanied by alterations to T cell immunity and by a low-grade chronic inflammatory state, termed inflammaging. Although inflammation is critical for dealing with infections and tissue damage, inflammaging appears to be physiologically deleterious and predictive of all-cause mortality in multiple elderly cohorts. The maintenance of this inflammatory state is mediated by metabolic changes. Immune metabolism is an emerging field of research with little information regarding the metabolism and metabolic checkpoints that regulate T cell ageing. The aim of my work is to investigating how changes to T cell metabolism during human ageing maintains this inflammatory state. Senescent CD8+ T cell displaying dysfunctional ‘giant’ mitochondria, which contribute to the bioenergetic instability of these cells. Publications Sillito FE, Holler A, O'Neill AT et al. (2024). Enhancement of mTORC1 Activity in Engineered Therapeutic CD4+ T Cells Amplifies Tumour Infiltration but Impairs Cytotoxicity. nameOfConference DOI: 10.1182/blood-2024-207047 QMRO: qmroHref Al-Khateeb ZF, Henson SM, Tremoleda JL et al. (publicationYear). The Immune Response in Two Models of Traumatic Injury of the Immature Brain. nameOfConference DOI: 10.3390/cells13191612 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/99908 Appios A, Davies J, Sirvent S et al. (2024). Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity. nameOfConference DOI: 10.1126/sciimmunol.adp0344 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/99315 Karatzia L, Cullen F, Young M et al. (2024). BS27 Induction of pre-clinical diabetes mellitus using combination of high fat diet and multiple low doses of anomer-equilibrated streptozotocin in C57/BL6J mice mimics human diabetic cardiomyopathy. Basic science DOI: 10.1136/heartjnl-2024-bcs.253 QMRO: qmroHref Covre LP, Fantecelle CH, Queiroz AM et al. (2024). NKG2C+CD57+ natural killer cells with senescent features are induced during cutaneous leishmaniasis and accumulate in patients with lesional healing impairment. nameOfConference DOI: 10.1093/cei/uxae040 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96942 Janssen H, Jhanji S, Oliver NS et al. (2024). Ward monitoring 4.0: real-time metabolic insights from continuous glucose monitoring into perioperative organ dysfunction. nameOfConference DOI: 10.1016/j.bja.2024.01.039 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95278 Al-Khateeb ZF, Boumenar H, Adebimpe J et al. (2024). The cellular senescence response and neuroinflammation in juvenile mice following controlled cortical impact and repetitive mild traumatic brain injury. nameOfConference DOI: 10.1016/j.expneurol.2024.114714 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/94743 Garrod-Ketchley C, d’Algue LM, Littlewood K et al. (2024). The generation of senescent-like CD4+ EMRA T cells in T2D and their contribution to poor COVID-19 vaccine responses. nameOfConference DOI: 10.1093/discim/kyad026 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91378 Henson SM (2023). Response to Letter to the Editor: Type 2 diabetes is associated with the accumulation of senescent T cells. nameOfConference DOI: 10.1093/cei/uxad078 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91377 Duggal NA, Henson SM, Turner JE (publicationYear). Editorial: Inflammation, aging, and disease: new perspectives and interventions. nameOfConference DOI: 10.3389/fragi.2023.1228756 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96943 Anderson S, Barnes M, Karlstaedt A et al. (2022). Targeting T-cell mediated inflammation improves cardiac dysfunction and metabolic remodelling in type 2 diabetes. nameOfConference DOI: 10.1016/j.yjmcc.2022.08.236 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/83806 Yildiz O, Schroth J, Tree T et al. (2023). Senescent-like Blood Lymphocytes and Disease Progression in Amyotrophic Lateral Sclerosis. nameOfConference DOI: 10.1212/nxi.0000000000200042 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82501 Bystrom J, Taher TE, Henson SM et al. (publicationYear). Metabolic requirements of Th17 cells and of B cells: Regulation and defects in health and in inflammatory diseases. nameOfConference DOI: 10.3389/fimmu.2022.990794 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82430 Yildiz O, Schroth J, Lombardi V et al. (publicationYear). The Expression of Active CD11b Monocytes in Blood and Disease Progression in Amyotrophic Lateral Sclerosis. nameOfConference DOI: 10.3390/ijms23063370 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/77644 Henson SM, Aksentijevic D (publicationYear). Senescence and Type 2 Diabetic Cardiomyopathy: How Young Can You Die of Old Age?. nameOfConference DOI: 10.3389/fphar.2021.716517 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74668 Sumagin R, Henson SM, Morrison VL et al. (publicationYear). Editorial: Targeting Leukocyte Trafficking: Insights and Future Directions. nameOfConference DOI: 10.3389/fimmu.2021.777002 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96944 Callender L, Carroll E, Ketchley-Garrod C et al. (2021). Altered nutrient uptake causes mitochondrial dysfunction in senescent CD8+ EMRA T cells during type 2 diabetes. nameOfConference DOI: 10.3389/fragi.2021.681428 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73368 Edwards AE, Vathenen R, Henson SM et al. (2021). Acute hyperglycaemic crisis after vaccination against COVID‐19: A case series. nameOfConference DOI: 10.1111/dme.14631 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73004 Callender LA, Schroth J, Carroll EC et al. (2021). GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage. nameOfConference DOI: 10.1038/s41467-021-23715-7 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71703 Jones T, Gutierrez A, Arroyo D et al. (2021). O10: METFORMIN TREATMENT IMPROVES LYMPHOCYTE METABOLISM IN A MOUSE MODEL OF MAJOR SURGERY. nameOfConference DOI: 10.1093/bjs/znab117.010 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91922 Schroth J, Weber V, Jones TF et al. (2021). Preoperative lymphopaenia, mortality, and morbidity after elective surgery: systematic review and meta-analysis. nameOfConference DOI: 10.1016/j.bja.2021.02.023 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71492 Schroth J, Henson SM (2020). Mitochondrial Dysfunction Accelerates Ageing.. nameOfConference DOI: 10.20900/immunometab20200035 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68158 Schroth J, Thiemermann C, Henson SM (2020). Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease. nameOfConference DOI: 10.3389/fcell.2020.564461 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67858 Mahler C, Andrews M, Henson S et al. (2020). Sequential Interleukin 2 and Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy. nameOfConference DOI: 10.1212/NXI.0000000000000756 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65645 Sheikh MH, Henson S, Loiola RA et al. (2020). Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier. nameOfConference DOI: 10.1186/s12974-020-01810-8 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64712 Pereira B, De Maeyer R, Covre L et al. (2020). Sestrins induce natural killer function in 1 senescent-like CD8+ T cells. nameOfConference DOI: 10.1038/s41590-020-0643-3 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67595 Callender L, Carroll E, BOBER E et al. (2020). Mitochondrial mass governs the extent of human T cell senescence. nameOfConference DOI: 10.1111/acel.13067 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/63820 Gadsbøll A-SØ, Jee MH, Funch AB et al. (2019). Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis. nameOfConference DOI: 10.1016/j.jid.2019.07.722 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/59502 Lau EYM, Carroll EC, Callender LA et al. (2019). Type 2 diabetes is associated with the accumulation of senescent T cells. nameOfConference DOI: 10.1111/cei.13344 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/58984 Seidel JA, Vukmanovic-Stejic M, Muller-Durovic B et al. (2018). Skin resident memory CD8+T cells are phenotypically and functionally distinct from circulating populations and lack immediate cytotoxic function. nameOfConference DOI: 10.1111/cei.13189 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/58479 Callender LA, Carroll EC, Bober EA et al. (2018). Divergent mechanisms of metabolic dysfunction drive fibroblast and T-cell senescence. nameOfConference DOI: 10.1016/j.arr.2018.06.001 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/41603 Callender LA, carroll EC, beal R et al. (2017). Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK.. nameOfConference DOI: 10.1111/acel.12675 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/26363 Lanna A, Henson S, Akbar A (2017). THE REGULATION OF T CELL SENESCENCE AND METABOLISM BY P38 MAPKINASE SIGNALING. nameOfConference DOI: 10.1093/geroni/igx004.4558 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68144 Henson SM (2017). Effects of Ageing on Adaptive Immune Responses. nameOfConference DOI: 10.1007/978-3-319-43365-3_2 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/73063 HENSON SM, Akbar AN, Lanna A (publicationYear). Senescence of T Lymphocytes: Implications for Enhancing Human Immunity. nameOfConference DOI: 10.1016/j.it.2016.09.002 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15905 Seidel JA, Henson S, Riddell N et al. (2016). Skin resident CD8+ T cells display low cytotoxic potential in healthy skin and fail to fully mature in primary melanoma lesions. nameOfConference DOI: 10.1016/j.jdermsci.2016.08.465 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68142 Vukmanovic-Stejic M, Seidel JA, Patel N et al. (2016). Skin resident CD8+T-cells display low cytotoxic potential in healthy skin and fail to fully mature in primary melanoma lesions. 20th Anniversary Conference of the British-Skin-Foundation on Skin Deep DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/17442 Müller-Durovic B, Lanna A, Polaco Covre L et al. (2016). Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase.. nameOfConference DOI: 10.4049/jimmunol.1600590 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15387 Schurich A, Pallett LJ, Jajbhay D et al. (2016). Distinct metabolic requirements of exhausted and functional virus-specific CD8 T cells in the same host. nameOfConference DOI: 10.1016/j.celrep.2016.06.078 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/13465 (2015). Correction: Genetic Regulation of Fate Decisions in Therapeutic T Cells to Enhance Tumor Protection and Memory Formation. nameOfConference DOI: 10.1158/0008-5472.can-15-3017 QMRO: qmroHref Henson SM (2015). CD8+ T-cell senescence: no role for mTOR.. nameOfConference DOI: 10.1042/bst20150092 QMRO: qmroHref Veliça P, Zech M, Henson S et al. (2015). Genetic Regulation of Fate Decisions in Therapeutic T Cells to Enhance Tumor Protection and Memory Formation. nameOfConference DOI: 10.1158/0008-5472.can-14-3283 QMRO: qmroHref Riddell NE, Griffiths SJ, Rivino L et al. (2015). Multifunctional cytomegalovirus (CMV)-specific CD8+ T cells are not restricted by telomere-related senescence in young or old adults. nameOfConference DOI: 10.1111/imm.12409 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15829 Henson SM, Macaulay R, Riddell NE et al. (2015). Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8+ T-cell proliferation by distinct pathways. nameOfConference DOI: 10.1002/eji.201445312 QMRO: qmroHref Schurich A, Henson SM (2014). The many unknowns concerning the bioenergetics of exhaustion and senescence during chronic viral infection. nameOfConference DOI: 10.3389/fimmu.2014.00468 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15828 Henson SM, Lanna A, Riddell NE et al. (2014). p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells. nameOfConference DOI: 10.1172/JCI75051 QMRO: qmroHref Lanna A, Henson SM, Escors D et al. (2014). The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. nameOfConference DOI: 10.1038/ni.2981 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15827 Franzese O, Henson SM, Naro C et al. (2014). Defect in HSP90 expression in highly differentiated human CD8+ T lymphocytes. nameOfConference DOI: 10.1038/cddis.2014.259 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15262 Seidel JA, Henson SM, Riddell N et al. (2014). Skin resident CD8+ T-cells display low cytotoxic potential in healthy skin and fail to fully mature in primary melanoma lesions. nameOfConference DOI: doi QMRO: qmroHref Henson SM, Akbar AN (2014). mTOR-independent regulation of senescent human CD8+ T-cells. nameOfConference DOI: doi QMRO: qmroHref Lanna A, Coutavas E, Levati L et al. (2013). IFN-α Inhibits Telomerase in Human CD8+ T Cells by Both hTERT Downregulation and Induction of p38 MAPK Signaling. nameOfConference DOI: 10.4049/jimmunol.1301409 QMRO: qmroHref Griffiths SJ, Riddell NE, Masters J et al. (2013). Age-Associated Increase of Low-Avidity Cytomegalovirus-Specific CD8+ T Cells That Re-Express CD45RA. nameOfConference DOI: 10.4049/jimmunol.1203267 QMRO: qmroHref Macaulay R, Riddell NE, Griffiths SJ et al. (2013). Differing HLA types influence inhibitory receptor signalling in CMV-specific CD8+ T cells. nameOfConference DOI: 10.1016/j.humimm.2012.11.014 QMRO: qmroHref Seidel JA, Riddell N, Henson S et al. (2013). Global circulating CD4+and CD8+T cells are more differentiated in old melanoma patients compared to healthy controls. nameOfConference DOI: doi QMRO: qmroHref Macaulay R, Akbar AN, Henson SM (2013). The role of the T cell in age-related inflammation. nameOfConference DOI: 10.1007/s11357-012-9381-2 QMRO: qmroHref Havenith SHC, Yong SL, Henson SM et al. (2012). Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells. nameOfConference DOI: 10.1093/intimm/dxs069 QMRO: qmroHref Henson SM, Riddell NE, Akbar AN (2012). Properties of end-stage human T cells defined by CD45RA re-expression. nameOfConference DOI: 10.1016/j.coi.2012.04.001 QMRO: qmroHref Henson SM, Macaulay R, Franzese O et al. (2012). Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade. nameOfConference DOI: 10.1111/j.1365-2567.2011.03550.x QMRO: qmroHref Seidel J, Riddell N, Henson S et al. (2012). Increased CD4 and CD8 T-cell differentiation in elderly patients with melanoma. nameOfConference DOI: doi QMRO: qmroHref Seidel JA, Riddell N, Henson S et al. (2012). Increased CD4+and CD8+T cell differentiation in old melanoma patients. nameOfConference DOI: doi QMRO: qmroHref Wills M, Akbar A, Beswick M et al. (2011). Report from the second cytomegalovirus and immunosenescence workshop. nameOfConference DOI: 10.1186/1742-4933-8-10 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15830 Di Mitri D, Azevedo RI, Henson SM et al. (2011). Reversible Senescence in Human CD4+CD45RA+CD27− Memory T Cells. nameOfConference DOI: 10.4049/jimmunol.1100978 QMRO: qmroHref Akbar AN, Henson SM (2011). Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?. nameOfConference DOI: 10.1038/nri2959 QMRO: qmroHref Wallace DL, Masters JE, De Lara CM et al. (2011). Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects. nameOfConference DOI: 10.1111/j.1365-2567.2010.03334.x QMRO: qmroHref Henson SM, Franzese O, Macaulay R et al. (2011). PD-1 acting through AKT mediates a proliferative defect in highly differentiated CD8+T cells. nameOfConference DOI: doi QMRO: qmroHref Seidel JA, Riddell N, Henson S et al. (2011). Peripheral T cell activation and differentiation in elderly melanoma patients. nameOfConference DOI: doi QMRO: qmroHref Di Mitri D, Henson S, Riddell NE et al. (2011). Reversible senescence in human CD4+ CD45RA+CD27- memory T cells. nameOfConference DOI: doi QMRO: qmroHref Hayhoe RPG, Henson SM, Akbar AN et al. (2010). Variation of human natural killer cell phenotypes with age: Identification of a unique KLRG1-negative subset. nameOfConference DOI: 10.1016/j.humimm.2010.03.014 QMRO: qmroHref van de Berg PJEJ, Griffiths SJ, Yong S et al. (2010). Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool. nameOfConference DOI: 10.4049/jimmunol.0903442 QMRO: qmroHref Henson SM, Akbar AN (2010). Memory T-Cell Homeostasis and Senescence during Aging. nameOfConference DOI: 10.1007/978-1-4419-6451-9_15 QMRO: qmroHref Henson SM, Akbar AN (2009). KLRG1—more than a marker for T cell senescence. nameOfConference DOI: 10.1007/s11357-009-9100-9 QMRO: qmroHref Henson SM, Franzese O, Macaulay R et al. (2009). KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells. nameOfConference DOI: 10.1182/blood-2009-01-199588 QMRO: qmroHref Henson SM, Macaulay R, Kiani-Alikhan S et al. (2008). The use of the inhibitory receptors for modulating the immune responses.. nameOfConference DOI: 10.2174/138161208786264124 QMRO: qmroHref Aspinall R, Pido-Lopez J, Imami N et al. (2007). Old Rhesus Macaques Treated with Interleukin-7 Show Increased TREC Levels And Respond Well to Influenza Vaccination. nameOfConference DOI: 10.1089/rej.2006.9098 QMRO: qmroHref Ghattas H, Wallace DL, Solon JA et al. (2007). Long-term effects of perinatal nutrition on T lymphocyte kinetics in young Gambian men 2. nameOfConference DOI: 10.1093/ajcn/85.2.480 QMRO: qmroHref ASPINALL R, HENSON S, PIDO‐LOPEZ J et al. (2004). Interleukin‐7: An Interleukin for Rejuvenating the Immune System. nameOfConference DOI: 10.1196/annals.1297.021 QMRO: qmroHref Henson SM, Snelgrove R, Hussell T et al. (2005). An IL-7 Fusion Protein That Shows Increased Thymopoietic Ability. nameOfConference DOI: 10.4049/jimmunol.175.6.4112 QMRO: qmroHref Herndler-Brandstetter D, Schwaiger S, Veel E et al. (2005). CD25-Expressing CD8+ T Cells Are Potent Memory Cells in Old Age. nameOfConference DOI: 10.4049/jimmunol.175.3.1566 QMRO: qmroHref Ngom PT, Collinson AC, Pido-Lopez J et al. (2004). Improved thymic function in exclusively breastfed infants is associated with higher interleukin 7 concentrations in their mothers' breast milk. nameOfConference DOI: 10.1093/ajcn/80.3.722 QMRO: qmroHref Henson SM, Pido-Lopez J, Aspinall R (2004). Reversal of thymic atrophy. nameOfConference DOI: 10.1016/j.exger.2003.10.030 QMRO: qmroHref Aspinall R, Henson SM, Pido-Lopez J (2003). My T's gone cold, I'm wondering why.... nameOfConference DOI: 10.1038/ni0303-203 QMRO: qmroHref Henson SM, Aspinall R (2003). Aging and the Immune System. nameOfConference DOI: 10.1007/978-94-017-0673-5_10 QMRO: qmroHref Russell WS, Henson SM, Hussein AS et al. (2000). Nippostrongylus brasiliensis: Infection Induces Upregulation of Acetylcholinesterase Activity on Rat Intestinal Epithelial Cells. nameOfConference DOI: 10.1006/expr.2000.4565 QMRO: qmroHref Sennitt MV, Kaumann AJ, Molenaar P et al. (1998). Erratum: The contribution of classical (β(1/2-)) and atypical β- adrenoceptors to the stimulation of human white adipocyte lipolysis and right atrial appendage contraction by novel β3-adrenoceptor agonists of differing selectives (Journal of Pharmacology and Experimental Therapeutic (1998) 285 (1084-1095)). nameOfConference DOI: doi QMRO: qmroHref Sennitt MV, Kaumann AJ, Molenaar P et al. (1998). The Contribution of Classical (β1/2-) and Atypical β-Adrenoceptors to the Stimulation of Human White Adipocyte Lipolysis and Right Atrial Appendage Contraction by Novel β3-Adrenoceptor Agonists of Differing Selectivities. nameOfConference DOI: doi QMRO: qmroHref Selkirk ME, Hussein AS, Russell WS et al. (1998). Secretory Acetylcholinesterases from the Nematode Parasite Nippostrongylus Brasiliensis. nameOfConference DOI: 10.1007/978-1-4899-1540-5_141 QMRO: qmroHref Molenaar P, Sarsero D, Arch JRS et al. (1997). Effects of (−)-RO363 at human atrial β-adrenoceptor subtypes, the human cloned β3-adrenoceptor and rodent intestinal β3-adrenoceptors. nameOfConference DOI: 10.1038/sj.bjp.0700850 QMRO: qmroHref Sponsors Diabetes UK Barts Charity BBSRC Collaborators Internal Gareth Ackland (WHRI) Egle Solito (WHRI) External Prof Arne Akbar (University College London) Back to top