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Dr Egle Solito

Egle

Reader in Immunobiology and Education Centre Lead (TMT)

Centre: Translational Medicine and Therapeutics

Email: e.solito@qmul.ac.uk
Telephone: +44(0) 20 7882 2117

Profile

ORCID iD: 0000-0001-5279-0049 

Egle Solito obtained her PhD at the University of Pavia. After important spells at the Sclavo Research Centre in Siena and Chiron in San Francisco, USA, she was awarded an EU fellowship (Marie Cure-Biotech program 1994) and she joined the Institut Cochin de Genetique Moleculaire, INSERM, in Paris, France.  Here she began a fruitful line of research centred on the transcriptional regulation of annexin A1 in cell transformation and differentiation. In January 2000, she moved to Imperial College London, UK, where she continued her long-term interest in annexin A1 biology and started to investigate the role of this protein in the HPA axis and the brain under the sponsorship of the Wellcome Trust (2003-2012), with particular interest in the role it plays in neuroinflammatory and neurodegenerative diseases. Her research spans all aspects of annexin A1 biology and pharmacology ranging from cell biology through to its role in human disease.

In October 2006 she was awarded a non-clinical Senior Lectureship in the division of Neuroscience and Mental Health at Imperial College London, UK.

In July 2011 she moved to the William Harvey Research Institute (founded by the Nobel Laureate Sir John Vane), Barts and the London School of Medicine and Dentistry, Queen Mary University, London, UK within the Centre for Translational Medicine, and Therapeutics.

Research

Group members

Irina Zalivina (Research Assistant); Anna Poliniewicz (PhD Student)

Summary

Impact of peripheral inflammation in the central immune response: immune cell trafficking across brain barriers
As the population's average age rapidly increases, so does the incidence of age-associated neurological disease. Hence, there is an urgent need to investigate the mechanisms of senescence and ageing to ameliorate the huge social and economic costs of “ageing welfare”. It was long thought that the brain was protected from systemic inflammation, but growing evidence shows that systemic inflammatory stimuli, such as infection, also trigger a central response. Many pathologies such as Diabetes and hypertension have been linked with cognitive impairment yet studies to date have failed to establish a direct link between traditional vascular risk factors. 

As the primary interface between the peripheral system and the brain, the blood-brain barrier is a major player in communication between the two compartments, and, alongside the major brain immune cell, the microglia, represent an ideal target system to investigate how peripheral disease and inflammation can affect brain function. We are particularly interested in identifying mechanisms and molecules responsible for the alteration of the BBB as well as the brain immune system. 

Lab Projects topics

Diet impact on cerebrovascular cell senescence: a risk factor for vascular dementia
An unhealthy diet, hypertension, and heart disease are the most common factors contributing to or accelerating vascular ageing and are thus major risk factors for brain vascular alterations (e.g. Vascular dementia VaD).  With our ageing population, cognitive decline is becoming an important co-morbidity in metabolic disorders. We have shown that young mice fed a high-fat high sugar diet exhibit chronic, low-grade inflammation, blood-brain barrier (BBB) leakage due to tight junction, and basal lamina disruption.This leads to the entry of peripheral immune cells and soluble factors into the brain parenchyma, resulting in glial activation and local inflammation. Most importantly, our data demonstrate that either pharmacological intervention or dietary reversal to a more balanced, healthy diet corrected the BBB leakage via stabilisation of tight junction assembly and the control of tissue inhibitor of metalloproteinase (TIMP-1) expression1. Moreover, we have shown that: 1) older patients with diet-induced type 2 diabetes (T2DM) present with brain vascular leakage, immune cell infiltration, and microglia activation, and 2) serum from T2DM patients significantly disrupt BBB function in vitro (Sheikh et al. FASEB J. 2022). 

Given these parallels with our murine studies, we hypothesise that consumption of a high-fat high-sugar diet in adult/old age may lead to progressive cerebral damage and cognitive impairment, effectively accelerating the ageing process. Moreover, we will explore whether dietary reversion interventions (as are clinically recommended for T2DM management) can contribute to ameliorating vascular damage, neuroinflammation, and cognitive impairment. In this project we aim to test the hypothesis that high fat-high sugar diet-induced low-grade inflammation, BBB damage, and microglial activation may trigger premature ageing and/or aggravate normal ageing, increasing susceptibility to VaD. Thus, we will further test the hypothesis that the progression of VaD can be controlled by the reversal of the high-fat-high-sugar diet intervention.

Pathophysiology of vascular dementia in the heart-brain axis
Vascular dementia (VaD) is an intracranial vessel disease and the second-most-common type of dementia. Not only cardiovascular risk factors consistently showed a strong association with dementia, but diverse cardiac diseases, including myocardial infarction (MI), atrial fibrillation (AF), heart failure (HF), and myocarditis have also been reported to increase the risk of dementia. Coronary artery disease may lead to dementia through its association with brain small vessel disease. Small vessel disease, in turn, disturbs cerebral blood flow (CBF) regulation and perfusion disrupts the blood–brain barrier and leads to an increased susceptibility to neurological insults. Blood vessels provide the vital infrastructure for the delivery of oxygen and essential nutrients throughout the body, and the term “blood-brain barrier” (BBB) is used to describe the unique characteristics of the blood vessels that vascularize the central nervous system. 

Multiple mediators such as oxidative injury, inflammatory, autoimmune mechanisms, and genetic predisposition have been proposed to play a role in vascular dementia.
However, the lack of early diagnosis and therapies highpoint the importance of identifying and controlling immune and vascular factors in heart diseases (e.g., atrial fibrillation) early in life to prevent dementia.

This project’s main aim is to identify circulating factors (e.g., fibrinogen, cytokines) that would damage the cerebral endothelium focusing particularly on the BBB and studying the interplay between the immune system and the BBB in VaD.

COVID 19 Long-Term Impact on the Brain. A Study at the Interface of the Cerebral Vasculature and Immune System 
Long COVID, known as ‘post-acute sequelae of COVID-19’, affects multiple body systems including the CNS, and causes prolonged acute and severe symptoms following infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At least 65 million people worldwide have long COVID, with more than 651 million cases of COVID-19 documented worldwide. Furthermore, a proportion of long COVID patients develop Myalgic Encephalomyelitis, a chronic autoimmune condition with neurological and immunological symptoms.

The WHO has declared COVID-19 an endemic, no longer representing a global health emergency. However, the threat of new variants capable of causing surges in disease remains. It is clear with the lack of diagnostic biomarkers or treatment options; this number will only increase.

A main feature of long COVID is neurological symptoms, which develop during or following SARS-CoV-2 infection. Persistent cognitive impairment called COVID-19 ‘brain fog’ is prominent amongst lasting neurological symptoms, characterised by impaired memory and brain functioning. SARS-CoV-2 infection is demonstrated to be linked with a reduction in grey matter thickness of the orbitofrontal cortex, an area of the brain important for cognition, in a landmark UK biobank study. 
The cerebral vascular system comprises blood vessels essential for brain function, there are approximately 400 miles of capillaries in the brain. The Blood-Brain barrier (BBB), at the capillary level, protects the brain from potentially harmful circulating substances infiltrating into the brain parenchyma.

Through post-mortem studies, the mechanisms for brain fog are thought to be that of BBB leakage, inducing activation microglial, the resident innate immune cells in the brain, and the induction of reactivity in astrocytes, triggering the release of damaging reactive oxygen species (ROS). Activated microglia are recognised as a hallmark of neuroinflammation. Neuro-inflammation is also characterised by increased cytokines and chemokines in the cerebrospinal fluid that bathes the brain. Ultimately this leads to neuron loss and neural circuit dysfunction. The AIM of this project is to identify changes in the regulation of BBB components and expression of activated microglia, understand how circulating factor (e.g. cytokines) induced by COVID-19 affects barrier permeability, and define the role of innate/adaptive immune cells in CNS.

Publications

  • Shah SN, Knausenberger TB-A, Pontifex MG et al. (2024). Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor. nameOfConference


  • Stolp HB, Solito E (2024). Developmental priming of early cerebrovascular ageing: Implications across a lifetime. nameOfConference


  • Fu H, Vuononvirta J, Fanti S et al. (2023). The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing.. nameOfConference


  • Cortese P, Amato F, Davino A et al. (publicationYear). The Immune Response to SARS-CoV-2 Vaccine in a Cohort of Family Pediatricians from Southern Italy. nameOfConference


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  • De Vitis C, Battaglia AM, Pallocca M et al. (publicationYear). ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis. nameOfConference


  • Wickstead ES, Solito E, Mcarthur S (2022). Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class. nameOfConference


  • Fanti S, Stephenson E, Rocha-Vieira E et al. (2022). Circulating c-Met–Expressing Memory T Cells Define Cardiac Autoimmunity. nameOfConference


  • Robbins JP, Solito E (publicationYear). Does Neuroinflammation Underlie the Cognitive Changes Observed With Dietary Interventions?. nameOfConference


  • Sheikh MH, Errede M, d'Amati A et al. (2022). Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood‐brain barrier: Therapeutic avenues. nameOfConference


  • Hoyles L, Pontifex M, Rodriguez-Ramiro I et al. (2021). Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide. nameOfConference


  • Chee SEJ, Solito E (publicationYear). The Impact of Ageing on the CNS Immune Response in Alzheimer’s Disease. nameOfConference


  • Mohammad S, Zoubi SA, Collotta D et al. (2021). A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice. nameOfConference


  • Reis M, Watts H, Mota B et al. (2021). Annexin-A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology. nameOfConference


  • Mohammad S, Al Zoubi S, Krieg N et al. (2021). A synthetic peptide designed to neutralise lipopolysaccharides attenuates metaflammation and diet-induced metabolic derangements in mice. nameOfConference

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  • Solito E, Marelli-Berg F, Fanti S et al. (2020). Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming. nameOfConference


  • Majkowska A, Redondo-Gómez C, Rice A et al. (publicationYear). Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures. nameOfConference


  • Sheikh MH, Henson S, Loiola RA et al. (2020). Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier. nameOfConference


  • Callender L, Carroll E, BOBER E et al. (2020). Mitochondrial mass governs the extent of human T cell senescence. nameOfConference


  • Solito E, Montague-Cardoso, K, Pitcher T et al. (2019). Changes in vascular permeability in the spinal cord contribute to chemotherapy- induced neuropathic pain. nameOfConference


  • Solito E, Zub E, Canet G et al. (publicationYear). The GR-ANXA1 pathway is a pathological player and a candidate target in epilepsy. nameOfConference


  • Solito E, Colamatteo A, Maggioli E et al. (2019). Reduced Annexin A1 expression associates with disease severity and inflammation in multiple sclerosis patients. nameOfConference


  • da Rocha GHO, Loiola RA, Pantaleão LDN et al. (2019). Control of expression and activity of peroxisome proliferated-activated receptor γ by Annexin A1 on microglia during efferocytosis.. nameOfConference


  • Loiola RA, Wickstead ES, Solito E et al. (2019). Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1. nameOfConference


  • SOLITO EGLE, PURVIS G, THIEMERMANN C (2019). Annexin-A1: therapeutic potential in microvascular disease.. nameOfConference


  • Purvis GSD, Collino M, Loiola RA et al. (publicationYear). Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes. nameOfConference


  • Pickering J, Ries M, Solito E et al. (2019). Administration of annexin-A1 reduces tau phosphorylation in the tau-P301L mouse model. nameOfConference

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  • SOLITO E (2018). Connections of Annexin A1 and Translocator Protein-18 KDa on Toll Like Receptor Stimulated BV-2 Cells.. nameOfConference


  • SOLITO E, SHEIKH M (2018). Annexin A1: Uncovering the Many Talents of an Old Protein. nameOfConference


  • S. D. Purvis G, Solito E (2018). Is AnnexinA1 The Miracle Drug For Diabetes?. nameOfConference


  • Purvis GSD, Chiazza F, Chen J et al. (2017). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. nameOfConference


  • Lima KM, Vago JP, Caux TR et al. (2017). The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1. nameOfConference


  • Purvis GSD, Chiazza F, Collino M et al. (2017). Endogenous Annexin-A1 is a Protective Determinant in HFD-induced Insulin Resistance and Diabetic Nephropathy. FASEB


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  • Purvis GSD, Chiazza F, Solito E et al. (2017). Endogenous annexin-A1 is a protective determinant in high-fat diet (HFD)-induced insulin resistance and diabetic nephropathy. European Shock Society


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  • Purvis GSD, Loiola RA, Keswich J et al. (2017). Role of annexin-A1 on blood-brain barrier functionality. nameOfConference

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  • McArthur S, Loiola RA, Maggioli, E et al. (2016). The restorative role of annexin A1 at the blood–brain barrier. nameOfConference


  • SOLITO E, Loiola R, Ries M et al. (2016). The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide. nameOfConference


  • Sinniah A, Yazid S, Perretti M et al. (2016). The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil. nameOfConference


  • Maggioli E, McArthur S, Mauro C et al. (2016). Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking. nameOfConference


  • Yazid S, Gardner PJ, Carvalho L et al. (2015). Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease. nameOfConference


  • Mauro C, De Rosa V, Marelli-Berg F et al. (publicationYear). Metabolic Syndrome and the Immunological Affair with the Blood–Brain Barrier. nameOfConference


  • Farsky SHP, Santin JR, Takahama C et al. (2014). ANNEXIN A1 AND PPARγ ON RESOLUTION OF INFLAMMATION. nameOfConference

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  • dos Santos Queiroz CJ, de Amorim Gomes Nakata CM, Solito E et al. (2014). Relationship between HPV and biomarkers annexin A1 and P53 in oropharyngeal cancer. nameOfConference


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  • Queiroz CJDS, Nakata CMDAG, Solito E et al. (2014). Relationship between HPV and the biomarkers annexin A1 and p53 in oropharyngeal cancer.. nameOfConference


  • Girol AP, Mimura KKO, Drewes CC et al. (2013). Anti-inflammatory mechanisms of the annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro.. nameOfConference


  • Cristante E, McArthur S, Mauro C et al. (2013). Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications.. nameOfConference


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  • Yazid S, Sinniah A, Solito E et al. (2013). Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1.. nameOfConference


  • Mehet DK, Philip J, Solito E et al. (2012). Evidence from in vitro and in vivo studies showing that nuclear factor-κB within the pituitary folliculostellate cells and corticotrophs regulates adrenocorticotrophic hormone secretion in experimental endotoxaemia.. nameOfConference


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  • Solito E, Sastre M (2012). Microglia function in Alzheimer's disease.. nameOfConference


  • McArthur S, Cristante E, Paterno M et al. (2010). Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia.. nameOfConference


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  • Yazid S, Leoni G, Getting SJ et al. (2010). Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization.. nameOfConference


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  • Yazid S, Ayoub SS, Solito E et al. (2010). Anti-allergic drugs and the Annexin-A1 system.. nameOfConference


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  • McArthur S, Yazid S, Christian H et al. (2009). Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization.. nameOfConference


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  • Yazid S, Solito E, Christian H et al. (2009). Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.. nameOfConference


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  • McArthur S, Prasongchean W, Gillies G et al. (2008). A critical role for the anti-inflammatory protein annexin A1 in microglial phagocytosis. nameOfConference

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  • Yazid S, Solito E, Christian H et al. (2008). Further studies on the rapid glucocorticoid effects in the U937 monocytic cell line and its potentiation by cromoglycate-like drugs. nameOfConference

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  • Solito E, McArthur S, Christian H et al. (2008). Annexin A1 in the brain--undiscovered roles?. nameOfConference


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  • Damazo AS, Flower RJ, Solito E et al. (2008). Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia. nameOfConference


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  • Hu NJ, Bradshaw J, Lauter H et al. (2008). Membrane-induced folding and structure of membrane-bound annexin A1 N-terminal peptides: Implications for annexin-induced membrane aggregation. nameOfConference


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  • John CD, Sahni V, Mehet D et al. (2007). Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides. nameOfConference


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  • Warne JP, John CD, Christian HC et al. (2006). Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue. nameOfConference


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  • Kamal AM, Hayhoe RPG, Paramasivam A et al. (2006). Antiflammin-2 activates the human formyl-peptide receptor like 1.. nameOfConference


  • Buckingham J, John C, Solito E et al. (2006). Annexin 1: a mediator of glucocorticoid action at the neuroendocrine-immune interface.. nameOfConference

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  • Petrella A, Festa M, Ercolino SF et al. (2006). Down-regulation of annexin-1 expression in thyroid cancers is associated with tumour aggressiveness. nameOfConference

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  • FLOWER RJ, Buckingham JC, Tierney T et al. (2006). Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. nameOfConference


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  • Solito E, Christian HC, Festa M et al. (2006). Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface.. nameOfConference


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  • Petrella A, Festa M, Ercolino SF et al. (2006). Annexin-1 downregulation in thyroid cancer correlates to the degree of tumor differentiation.. nameOfConference


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  • Buckingham JC, Sahni V, Morris JF et al. (2006). Annexin 1 dependent actions of glucocorticoids in the anterior pituitary gland - role of the formyl peptide receptor family. nameOfConference


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  • Buckingham JC, Mulla A, Tierney T et al. (2006). The cellular exportation of annexin 1 requires post-translational modification. nameOfConference


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  • Rodrigues-Lisoni FC, Mehet DK, Peitl P et al. (2006). In vitro and in vivo studies on CCR10 regulation by Annexin A1 (vol 580, pg 1431, 2006). nameOfConference


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  • Hayhoe RPG, Kamal AM, Solito E et al. (2006). Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. nameOfConference


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  • Rodrigues-Lisoni FC, Mehet DK, Peitl P et al. (2006). In vitro and in vivo studies on CCR10 regulation by Annexin A1.. nameOfConference


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  • Buckingham JC, John CD, Solito E et al. (2006). Annexin 1, glucocorticoids, and the neuroendocrine-immune interface. nameOfConference


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  • Petrella A, Festa M, Ercolino SF et al. (2005). Induction of annexin-1 during TRAIL-induced apoptosis in thyroid carcinoma cells.. nameOfConference


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  • Rodrigues-Lisoni FC, Oliani S, Buckingham J et al. (2005). Annexin A1: From gene organization to physiology. nameOfConference

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  • Mulla A, Leroux C, Solito E et al. (2005). Correlation between the antiinflammatory protein annexin 1 (lipocortin 1) and serum cortisol in subjects with normal and dysregulated adrenal function.. nameOfConference


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  • Perretti M, Solito E (2004). Annexin 1 and neutrophil apoptosis. nameOfConference


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  • John CD, Christian HC, Morris JF et al. (2004). Annexin 1 and the regulation of endocrine function. nameOfConference


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  • Parente L, Solito E (2004). Annexin 1: more than an anti-phospholipase protein.. nameOfConference


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  • Mulla A, Christian HC, Solito E et al. (2004). Expression, subcellular localization and phosphorylation status of annexins 1 and 5 in human pituitary adenomas and a growth hormone-secreting carcinoma.. nameOfConference


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  • Tierney T, Christian HC, Morris JF et al. (2003). Evidence from studies on co-cultures of TtT/GF and AtT20 cells that Annexin 1 acts as a paracrine or juxtacrine mediator of the early inhibitory effects of glucocorticoids on ACTH release.. nameOfConference


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  • John CD, Christian HC, Morris JF et al. (2003). Kinase-dependent regulation of the secretion of thyrotrophin and luteinizing hormone by glucocorticoids and annexin 1 peptides.. nameOfConference


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  • Buckingham JC, Solito E, John C et al. (2003). Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system.. nameOfConference


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  • Buckingham JC, Solito E, John C et al. (2003). Annexin 1: a paracrine/juxtacrine mediator of glucorticoid in the action in the neuroendocrine system. nameOfConference


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  • de Coupade C, Solito E, Levine JD (2003). Dexamethasone enhances interaction of endogenous annexin 1 with L-selectin and triggers shedding of L-selectin in the monocytic cell line U-937.. nameOfConference


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  • Solito E, Kamal A, Russo-Marie F et al. (2003). A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. nameOfConference


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  • Croxtall JD, Gilroy DW, Solito E et al. (2003). Attenuation of glucocorticoid functions in an Anx-A1-/- cell line.. nameOfConference


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  • Solito E, Mulla A, Morris JF et al. (2003). Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase c, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase. nameOfConference


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  • Solito E, Perretti M (2003). Exogenous annexin 1 promotes human neutrophil apoptosis. nameOfConference

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  • PERRETTI M, Marullo S, Buckingham JC et al. (2003). A novel calcium-dependent pro-apoptotic effect of annexin 1 on human neutrophils.. nameOfConference


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  • FLOWER RJ, John C, Solito E et al. (2003). Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system.. nameOfConference


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  • FLOWER RJ, Morris JF, Christian HC et al. (2003). Kinase-Dependent Regulation of the Secretion of Thyrotrophin and Luteinizing Hormone By Glucocorticoids and Annexin 1 Peptides.. nameOfConference


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  • Perretti M, Chiang N, La M et al. (2002). Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor.. nameOfConference


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  • Perretti M, Ingegnoli F, Wheller SK et al. (2002). Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model.. nameOfConference


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  • Perretti M, La M, Solito E (2002). Annexin 1 interacts with L-selectin following neutrophil adhesion to endothelial cells. nameOfConference

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  • Perretti M, Blades MC, Wheller SK et al. (2002). Monocytic cells over-expressing annexin 1 have reduced transmigration in vitro and elicitation in vivo. nameOfConference

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  • Solito E, Mulla A, Buckingham JC (2002). Dexamethasone induces serine phosphorylation of annexin 1: Involvement of PKC and PI3-kinase. nameOfConference

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  • Mulla A, Buckingham JC, Solito E (2002). LPS acts via IL-6 and IL-1 to modulate the expression and phosphorylation of annexin 1 in cell lines derived from the putative microglia of the neuroendocrine system.. nameOfConference

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  • Solito E, Mulla A, Flower RJ et al. (publicationYear). Lipocortin 1 (Annexin 1). nameOfConference


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  • FLOWER RJ, Buckingham J, Christian H et al. (2002). Annexin 1-dependent actions of glucocorticoids in the anterior pituitary gland: roles of the N-terminal domain and protein kinase C.. nameOfConference


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  • de Coupade C, Ajuebor MN, Russo-Marie F et al. (2001). Cytokine modulation of liver annexin 1 expression during experimental endotoxemia. nameOfConference


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  • Kamal AM, Smith SF, De Silva Wijayasinghe M et al. (2001). An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitro.. nameOfConference


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  • Perretti M, Getting SJ, Solito E et al. (2001). Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. nameOfConference


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  • John CD, Solito E, Mulla A et al. (2001). Dexamethasone induces serine phosphorylation of annexin 1 in pituitary cells and suppresses ACTH release by a PKC-dependent mechanism.. nameOfConference

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  • Solito E, de Coupade C, Canaider S et al. (2001). Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation. nameOfConference


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  • Solito E, Tissot M, Russo-Marie F et al. (2000). Extracellular annexin-1 accelerates apoptosis of human polymorphonuclears neutrophils.. nameOfConference

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  • D'Amico M, Di Filippo C, La M et al. (2000). Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment.. nameOfConference


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  • Solito E, Romero IA, Marullo S et al. (2000). Annexin 1 binds to U937 monocytic cells and inhibits their adhesion to microvascular endothelium: involvement of the alpha 4 beta 1 integrin.. nameOfConference


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  • Mulla A, Christian H, Morris J et al. (2000). Expression of annexins 1 and 5 in human pituitary tumours. nameOfConference

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  • Solito E, Tissot M, Russo-Marie F et al. (2000). Extracellular Annexin 1 induces apoptosis of human polymorphonuclear neutrophils. nameOfConference

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  • Le Maire V, Solito E, Russo-Marie F et al. (2000). System A neutral amino acid transporter regulation by interleukin-1beta in human osteoarthritic synovial cells: evidence for involvement of prostaglandin E(2) as a second messenger.. nameOfConference


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  • Canaider S, Solito E, de Coupade C et al. (2000). Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I).. nameOfConference


    QMRO: qmroHref
  • Perretti M, Solito E, La M et al. (2000). Annexin 1 activates human neutrophils: A mechanism for its anti-inflammatory in vivo effect. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • de Coupade C, Gillet R, Bennoun M et al. (2000). Annexin 1 expression and phosphorylation are upregulated during liver regeneration and transformation in antithrombin III SV40 T large antigen transgenic mice.. nameOfConference


    QMRO: qmroHref
  • D'Amico M, Di Filippo C, Solito E et al. (2000). Lipocortin 1 inhibits myocardial infarct by reducing local neutrophil infiltration. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Gidon-Jeangirard C, Solito E, Hofmann A et al. (1999). Annexin V counteracts apoptosis while inducing Ca(2+) influx in human lymphocytic T cells.. nameOfConference


    QMRO: qmroHref
  • Young KA, Hirst WD, Solito E et al. (1999). De novo expression of lipocortin-1 in reactive microglia and astrocytes in kainic acid lesioned rat cerebellum.. nameOfConference


    QMRO: qmroHref
  • John CD, Cover PO, Taylor AD et al. (1999). Evidence from in vivo and in vitro studies that the inhibitory actions of lipocortin 1 on anterior pituitary function require amino acid residues 13-26. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Canaider S, Solito E, Goulding NJ et al. (1999). Increased apoptosis in cells overexpressing lipocortin 1. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Raguenes-Nicol C, Russo-Marie F, Domage G et al. (1999). Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway.. nameOfConference


    QMRO: qmroHref
  • Raugei G, Degl'Innocenti D, Chiarugi P et al. (1999). Preferential accumulation of muscle type acylphosphatase in the nucleus during differentiation.. nameOfConference


    QMRO: qmroHref
  • Lim LH, Solito E, Russo-Marie F et al. (1998). Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1.. nameOfConference


    QMRO: qmroHref
  • Solito E, Raguenes-Nicol C, de Coupade C et al. (1998). U937 cells deprived of endogenous annexin 1 demonstrate an increased PLA2 activity.. nameOfConference


    QMRO: qmroHref
  • Solito E, de Coupade C, Parente L et al. (1998). IL-6 stimulates annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein.. nameOfConference


    QMRO: qmroHref
  • Solito E, de Coupade C, Parente L et al. (1998). Human annexin 1 is highly expressed during the differentiation of the epithelial cell line A 549: involvement of nuclear factor interleukin 6 in phorbol ester induction of annexin 1.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dubois T, Mira JP, Feliers D et al. (1998). Annexin V inhibits protein kinase C activity via a mechanism of phospholipid sequestration.. nameOfConference


    QMRO: qmroHref
  • Lim LHK, Getting SJ, Das AM et al. (1997). Inhibition of neutrophil : endothelium interaction in murine post-capillary venules by lipocortin 1. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Voermans PH, Go KG, Horst GJT et al. (1997). P-3-325 Steroid-induced expression of annexinin brain. nameOfConference


    QMRO: qmroHref
  • Voermans PH, Go KG, ter Horst GJ et al. (1997). Expression of Annexin and Annexin-mRNA in Rat Brain Under Influence of Steroid Drugs. nameOfConference


    QMRO: qmroHref
  • Voermans PH, Go KG, ter Horst GJ et al. (1997). Expression of annexin and annexin-mRNA in rat brain under influence of steroid drugs.. nameOfConference


    QMRO: qmroHref
  • Cifone MG, Cironi L, Roncaioli P et al. (1996). Phospholipase A(2) activity and calpactin I levels in rat lymphokine-activated killer cells: Correlation with the cytotoxic activity. nameOfConference


    QMRO: qmroHref
  • Ambrosetti DC, Palla E, Mirtella A et al. (1996). Synthetic alleles at position 121 define a functional domain of human interleukin-1 beta.. nameOfConference


    QMRO: qmroHref
  • Voermans PH, Go KG, Horst GJ et al. (1996). Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F.. nameOfConference


  • Parente L, Ambrosetti D, Palla E et al. (1995). A new functional binding site for interleukin-1beta?. nameOfConference


    QMRO: qmroHref
  • Parente L, Solito E (1994). Association between glucocorticosteroids and lipocortin 1.. nameOfConference


    QMRO: qmroHref
  • Solito E, Nuti S, Parente L (1994). Dexamethasone-induced translocation of lipocortin (annexin) 1 to the cell membrane of U-937 cells.. nameOfConference


    QMRO: qmroHref
  • PARENTE L, NUTI S, SOLITO E (1994). DEXAMETHASONE INDUCES THE TRANSLOCATION OF LIPOCORTIN-1 TO THE MEMBRANE OF HUMAN MONOCYTIC U-937 CELLS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • GO KG, ZUIDERVEEN F, DELEY L et al. (1994). EFFECT OF STEROIDS ON BRAIN LIPOCORTIN IMMUNOREACTIVITY. nameOfConference


    QMRO: qmroHref
  • Go KG, Zuiderveen F, De Ley L et al. (1994). Effect of steroids on brain lipocortin immunoreactivity.. nameOfConference


  • SOLITO E, PALLA E, BENSI G et al. (1994). IDENTIFICATION OF ACTIVE-SITES OF INTERLEUKIN-1-BETA BY LOOP SUBSTITUTION AND SITE-DIRECTED MUTAGENESIS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Go KG, Ter Haar JG, de Ley L et al. (1994). The effect of steroid treatment on lipocortin immunoreactivity of rat brain.. nameOfConference


  • De Caterina R, Sicari R, Giannessi D et al. (1993). Macrophage-specific eicosanoid synthesis inhibition and lipocortin-1 induction by glucocorticoids.. nameOfConference


    QMRO: qmroHref
  • Palla E, Bensi G, Solito E et al. (1993). Loop substitution as a tool to identify active sites of interleukin-1 beta.. nameOfConference


    QMRO: qmroHref
  • BECHERUCCI C, PERRETTI M, SOLITO E et al. (1993). CONCEIVABLE DIFFERENCE IN THE ANTIINFLAMMATORY MECHANISMS OF LIPOCORTIN-1 AND LIPOCORTIN-5. nameOfConference


    QMRO: qmroHref
  • RUBARTELLI A, BAJETTO A, BONIFACI N et al. (1993). A NOVEL WAY TO GET OUT OF THE CELL. nameOfConference


    QMRO: qmroHref
  • Rubartelli A, Bajetto A, Bonifaci N et al. (1993). A novel way to get out of the cell.. nameOfConference


    QMRO: qmroHref
  • Becherucci C, Perretti M, Solito E et al. (1993). Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5.. nameOfConference


  • Solito E, De Caterina R, Giannessi D et al. (1993). Studies on the induction of lipocortin-1 by glucocorticoids.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Parente L, Solito E, Giannessi P et al. (1992). Inhibition of eicosanoid formation and lipocortin induction by glucocorticoids in human cell lines and in patients with inflammatory lung disease.. nameOfConference


    QMRO: qmroHref
  • Parente L, Galeotti CL, Ghiara P et al. (1992). Mechanisms of IL-1 different biological activities. Studies using IL-1 muteins and IL-1 receptor antibodies. nameOfConference


    QMRO: qmroHref
  • Perretti M, Solito E, Parente L (1992). Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice.. nameOfConference


    QMRO: qmroHref
  • Solito E, Raugei G, Melli M et al. (1992). Glucocorticoid effect on lipocortin mRNA expression in U-937 cells.. nameOfConference


    QMRO: qmroHref
  • de Caterina R, Sicari R, Giannessi D et al. (1992). Induction of synthesis of lipocortin-I and inhibition of eicosanoid production in inflammatory cells: Evidence for a cell selectivity in glucocorticoid action. nameOfConference


    QMRO: qmroHref
  • SOLITO E, RAUGEI G, MELLI M et al. (1991). DEXAMETHASONE INDUCES THE EXPRESSION OF THE MESSENGER-RNA OF LIPOCORTIN-1 AND LIPOCORTIN-2 AND THE RELEASE OF LIPOCORTIN-1 AND LIPOCORTIN-5 IN DIFFERENTIATED, BUT NOT UNDIFFERENTIATED U-937 CELLS. nameOfConference


    QMRO: qmroHref
  • Solito E, Raugei G, Melli M et al. (1991). Dexamethasone induces the expression of the mRNA of lipocortin 1 and 2 and the release of lipocortin 1 and 5 in differentiated, but not undifferentiated U-937 cells.. nameOfConference


    QMRO: qmroHref
  • Perretti M, Becherucci C, Mugridge KG et al. (1991). A novel anti-inflammatory peptide from human lipocortin 5.. nameOfConference


    QMRO: qmroHref
  • SOLITO E, RAUGEI G, MELLI M et al. (1991). EFFECT OF DEXAMETHASONE AND PHORBOL-MYRISTATE ACETATE ON LIPOCORTIN-1, LIPOCORTIN-2 AND LIPOCORTIN-5 MESSENGER-RNA AND PROTEIN-SYNTHESIS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Solito E, Raugei G, Melli M et al. (1991). Effect of dexamethasone and phorbol myristate acetate on lipocortin 1, 2 and 5 mRNA and protein synthesis.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Boraschi D, Villa L, Ghiara P et al. (1991). Mechanism of acute toxicity of IL-1 beta in mice.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Parente L, Mugridge KG, Perretti M et al. (1990). In vitro and in vivo activation of phospholipase A2 by interleukin-1. nameOfConference


    QMRO: qmroHref
  • Parente L, Becherucci C, Perretti M et al. (1990). Are the lipocortins the second messengers of the anti-inflammatory action of glucocorticoids?. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Becherucci C, Solito E, Perretti M et al. (1990). Purification and biological activity of human lipocortin 2.. nameOfConference


    QMRO: qmroHref
  • Solito E, Parente L (1989). Modulation of phospholipase A2 activity in human fibroblasts.. nameOfConference


    QMRO: qmroHref
  • SOLITO E, PARENTE L (1988). ACTIVATION OF PHOSPHOLIPASE-A2 BY INTERLEUKIN-1 IN HUMAN-FIBROBLASTS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Solito E, Busoni P, Bini L (1985). [Relational perspective in a district service for the substance-dependent].. nameOfConference

    DOI: doi

    QMRO: qmroHref

Sponsors

Collaborators

Internal

External

  • Prof. Magdalena Sastre (Imperial College, London)
  • Prof. Daniela Virgintino (University of Bari School of Medicine, Italy)
  • Dr Helen Stolp (Royal Veterinary College, University of London)
  • Prof. Caroline Menard (Laval University-Canada)
  • Dr Veronica DeRosa (IEOS-CNR-Naples Italy)
  • Dr Nicola Marchi INSERM Montpellier (France)

News

  • Silvia Fanti won a poster prize at the 24th international symposium on Blood-Brain Barriers (22-24 September 2022 Bari-Italy), September 2022
  • Madehaa Sheikh was awarded a Guarantors of Brain travel fellowship to participate in the 13th CVB-2019 Miami FL (USA), June 2019
  • Madehaa Sheikh was awarded a Guarantors of Brain travel fellowship to participate in the 12th CVB-2017 Melbourne (AU), November 2017
  • Scientists breach the brain barrier to treat sick patient, BBC News, 10 November 2015
  • Elisa Maggioli was awarded a BPS travel Fellowship to participate to 8th International Conference on Annexins Maastricht, Netherlands, 8th - 11th Sep 2015.
  • Elisa Maggioli was awarded a Guarantors of Brain travel fellowship to participate in the 11th CVB 2013-Paris (France), 2013
  • Elisa Maggioli won a poster prize at the London Vascular Biology Forum, December 2013
  • Restoring the Blood-Brain Barrier, JAMA, 6 February 2013
  • Annexin A1 (ANXA1): SciBX: Science-Business eXchange - Nature › Journal home › Past Issues › Distillery: Therapeutics‎ Distillery: Therapeutics - Neurology. SciBX 6(3); doi :10.1038/scibx.2013.64. Published online 24 January 2013
  • Research opens up possibility of therapies to restore blood-brain, Queen Mary University of London (Press Release), 2 January 2013

Teaching

Prof. Solito teaches at undergraduate and postgraduate (GEP-MRes) levels and supervises BMedSci, MRes and PhD students.

•    Module Lead BSc in Pharmacology & Innovative Therapeutics (BMD171)
•    Education Centre Lead
•    Member of the Education Committee
•    Member of the International PhD VIVA committee

Disclosures

  • 2017 Dr Solito has received consultancy funds from TRIO-Medicines-Limited.
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