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Professor Leonardo Guasti

Leonardo

Professor in Experimental Endocrinology

Centre: Endocrinology

Email: l.guasti@qmul.ac.uk
Telephone: +44(0) 20 7882 2115
Twitter: @GuastiL

Profile

ORCID iD: 0000-0002-4616-6044

I obtained my degree at the University of Florence, Italy, in 1999 (BSc Biological sciences, MS in Pathophysiology). I was then awarded an Accademia Nazionale dei Lincei and a Telethon Fellowship from the University of Florence, Milano-Bicocca and Tulsa, (USA) to study the role of Ether-a’-go-go-Related Gene (ERG) in cancer progression, neural function and hormone secretion. I then undertook a PhD in Clinical and Experimental Oncology at the University of Florence, and spent half of the time at the University of Tulsa (USA) as a Fulbright Distinguished Fellow. My PhD studies uncovered a novel mechanism of post-translational regulation of ERG channels expression controlling ERG current density, neurite outgrowth and apoptosis. In 2006 I relocated to Queen Mary University of London, first at the school of Biological and Chemical Sciences and then at the William Harvey Research Institute’s Centre for Endocrinology, studying signalling pathways regulating adrenal cortex development and function. After a year at the UCL Institute of Child Health, I became a lecturer in Endocrinology in 2012, a Senior Lecturer in 2015 and a Reader in 2019.

Research

Current members of the Group

  • Dr James Pittaway (MRC-funded Clinical Research Fellow); Dr Katia Mariniello (Barts Charity Postdoctoral Fellow); Dr Jordan Read (Barts Charity Postdoctoral Fellow, with Profs Chapple and Metherell), Dr Charlotte Hall (Barts Charity Postdoctoral Fellow, with Profs Chapple and Metherell).

Alumni

  • Dr Gerard Ruiz-Babot (BBSRC Postdoctoral Researcher, now postdoc at Harvard); Dr Irene Hadjidemetriou (MRC PhD student, now Scientist at NIPD Genetics, Cyprus); Dr Jayna Mistry, (PhD student, now Product manager at Almac group); Dr Demetris Mariannis (iBSc student, now doctor at NHS), Dr Alessandra Mancini (PhD student, now postdoc at Harvard), Ms Sharon Jane Ajodha (Research technician, now Centre Administrator, WHRI), Aswhini Maudhoo (SfE and MSc fellow, now final year medical student).

Summary 

Reprogramming strategies aimed at obtaining steroidogenic-like cells
The adrenal cortex is the primary site of steroid synthesis and controls essential metabolic processes. The ability to generate an individual-specific cell platform through the generation of human induced pluripotent stem cells or lineage conversion (transdifferentiation) offers a new paradigm for functional studies, for modelling human disease and for drug testing. There is an unmet need for developing such technology in the adrenal field, as current in vitro systems are not physiologically relevant and some animal models do not phenocopy the adrenal disease. With this in mind, we have been able to generate human inducible steroidogenic cells (hiSCs) starting from skin fibroblasts, blood and urine-derived cells (Fig 1). hiSCs expressed steroidogenic enzymes, secrete corticol in a ACTH-dependent fashion and are viable when transplanted intra-adrenally or under the kidney capsule. hiSCs derived from patients with congenital adrenal hyperplasia showed an altered steroid profile, which was rescued by expressing the wild-type form of the enzyme.

We are currently working on alternative reprogramming strategies to generate adrenocortical-like cells and testing them on in vivo models of adrenal insufficiency. 

Modeliing congenital adrenal hyperlapsia and testing...

Figure 1 

Molecular mechanisms in adrenocortical carcinogenesis
The adrenal cortex undergoes continuous self-renewal throughout life. The histologically and functionally distinct zona glomerulosa and zona fasciculata are replenished from a pool of undifferentiated capsular and subcapsular cells. Capsular cells expressing the transcription factor Gli1 are one source of steroidogenic cells. The differentiation of Gli1+ cells into fully mature steroidogenic cells is initiated through a distinct population of undifferentiated cells located underneath the capsule and secreting the cell-fate regulator sonic hedgehog (Shh). Corrupting the differentiation of these cells as part of adrenal self-renewal is a plausible contributor to the pathogenesis of adrenocortical carcinoma (ACC). Activation of WNT/bCatenin, another pathway active at the capsule/subcapsular boundary involved in adrenocortical growth, self-renewal and zonation, is a frequently observed molecular change in ACC. In addition to Gli1+ and Shh+ cells, another marker of undifferentiated cells recognised in rats is delta-like homologue 1 (DLK1). This is a paternally expressed, cleavable single-pass transmembrane protein, which is a member of the Notch/Delta/Serrate family. DLK1 expression is seen in many human tissues during embryonic development but in adults, expression is low in most healthy tissues. It is known to inhibit differentiation and expression is reported in numerous malignancies.

We have identified DLK1 as a distinct marker for cell clusters in human adrenals, seemingly clonal in appearance, which we have named DLK1-expressing Cell Clusters (DCCs) (Fig 2A). Cells expressing DLK1 remodel from a continuous subcapsular layer to form cell clusters after puberty in physiologically normal human adrenals (Fig 2B-E). This previously unrecognised cell population comprises cells that are poorly steroidogenic and histologically dissimilar from neighbouring zona glomerulosa and fasciculata. Cells expressing DLK1 have characteristics of cancer stem cells in vitro, namely DLK1 expression is significantly increased in spheroid cultures and in viable ACC cells after mitotane treatment (Fig 2F-I). DLK1+ve cells have a higher LD50 to mitotane than DLK1–ve cells (Fig 2J). Moreover, DLK1 is heterogeneously expressed in ACCs samples (Fig 2L).

The role of DLK1 and its interacting partners in the pathogenesis of ACC is being investigated through the use of mouse genetic lineage tracing, in vitro and ex vivo assays. 

The role of DLK1

 

Figure 2

Publications

  • d'Aniello F, Mariniello K, Al Sayed Y et al. (2024). The Role of DLK1 Deficiency in Central Precocious Puberty and Association with Metabolic Dysregulation. nameOfConference


  • Gualtieri A, Gomez-Corral L, Nicholson J et al. (2024). 12408 Efnb2 Controls Pituitary Gland Development By Regulating Proliferation Of Pituitary Stem Cells. nameOfConference


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  • Gualtieri A, Gomez-Corral L, Nicholson J et al. (publicationYear). Efnb2 controls pituitary development by regulating the pituitary stem cell niche. nameOfConference


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  • Cazzaniga M, Cardinali M, Di Pierro F et al. (publicationYear). The Potential Role of Probiotics, Especially Butyrate Producers, in the Management of Gastrointestinal Mucositis Induced by Oncologic Chemo-Radiotherapy. nameOfConference


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  • Ruiz-Babot G, Eceiza A, Abollo-Jiménez F et al. (2023). Generation of glucocorticoid-producing cells derived from human pluripotent stem cells. nameOfConference


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  • Read J, Guasti L, Paganoni A et al. (publicationYear). Rare variants in the MECP2 gene in girls with central precocious puberty. nameOfConference


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  • DI Pierro F, Guasti L, Zerbinati N et al. (2023). Role of S. salivarius K12 in the prevention of URTI and AGE in nursery-aged children.. nameOfConference


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  • DI Pierro F, Agnelli G, Conti DM et al. (2023). Psychological distress trend in non-celiac gluten sensitivity: is there a role for a gliadin-degrading probiotic strain?. nameOfConference


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  • DI Pierro F, Bertuccioli A, Cazzaniga M et al. (2023). A clinical report highlighting some factors influencing successful vaginal colonization with probiotic Lactobacillus crispatus.. nameOfConference


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  • DI Pierro F, Zerbinati N, Guasti L et al. (2023). Can the analysis of the gut microbiota have a clinical application in real life?. nameOfConference


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  • Canton APM, Tinano FR, Guasti L et al. (2023). Rare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study. nameOfConference


  • Mistry JN, Silvennoinen S, Zaman F et al. (publicationYear). The crosstalk between FGF21 and GH leads to weakened GH receptor signaling and IGF1 expression and is associated with growth failure in very preterm infants. nameOfConference


  • Williams JL, Smith C, Hall C et al. (2023). Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma. nameOfConference


  • Hasan S, Delicata F, Guasti L et al. (publicationYear). Locus Coeruleus Neurons’ Firing Pattern Is Regulated by ERG Voltage-Gated K+ Channels. nameOfConference


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  • Canton A, Tinano F, Guasti L et al. (2022). RF14 | PSAT120 X-Linked Central Precocious Puberty Associated with MECP2 Defects. nameOfConference


  • Pittaway J, Mariniello K, Altieri B et al. (publicationYear). Delta-like non-canonical Notch ligand 1 (DLK1) - a novel biomarker in adrenocortical carcinoma. nameOfConference


  • Mariniello K, Pittaway J, Hadjidemetriou I et al. (publicationYear). Delta-like non-canonical notch ligand 1 (DLK1)-expressing adrenocortical progenitor cells: role in adrenal turnover, remodeling and tumorigenesis in mice. nameOfConference


  • E RJ, Pinheiro-Machado CA, Tinano F et al. (publicationYear). Variants in Methyl-CpG-binding protein 2 (MECP2) are associated with X-Linked Central Precocious Puberty. nameOfConference


  • Guasti L, Pittaway JFH (2022). A new recipe for TARTs? One step closer in identifying the origin of testicular adrenal rest tumours. nameOfConference


  • Guasti L, Dilaveris P, Mamas MA et al. (2022). Digital health in older adults for the prevention and management of cardiovascular diseases and frailty. A clinical consensus statement from the ESC Council for Cardiology Practice/Taskforce on Geriatric Cardiology, the ESC Digital Health Committee and the ESC Working Group on e‐Cardiology. nameOfConference


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  • Mariniello K, Guasti L, Rognoni E (publicationYear). DLK1 expressing cells mark a population of progenitor cells in the adrenal cortex and contribute to the zonation of the adrenal gland. nameOfConference


  • Williams J, Smith C, Hall C et al. (publicationYear). Elevated SGPL1 expression is associated with increased metabolic rate in cells and reduced survival in individuals with adrenocortical carcinoma. nameOfConference


  • Guasti L (2022). Novel therapeutic models for adrenal disorders. nameOfConference

    DOI: doi

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  • Canton A, Tinano F, Guasti L et al. (2022). X-Linked Central Precocious Puberty Associated with MECP2 defects. nameOfConference

    DOI: doi

  • Saengkaew T, Ruiz-Babot G, David A et al. (publicationYear). Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty. nameOfConference


  • Howard S, Saengkaew T, Dunkel L et al. (publicationYear). Dominant mutations in CCDC141 are found by ehole rxome dequencing to be a common cause of self-limited delayed puberty. nameOfConference


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  • Pittaway JFH, Lipsos C, Mariniello K et al. (publicationYear). The role of delta-like non-canonical Notch ligand 1 (DLK1) in cancer.. nameOfConference


  • Richter D, Guasti L, Koehler F et al. (2021). Late phase of COVID‐19 pandemic in General Cardiology. A position paper of the ESC Council for Cardiology Practice. nameOfConference


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  • van der Grinten HLC, Speiser PW, Ahmed SF et al. (2022). Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management. nameOfConference


  • Saengkaew T, Mancini A, Ruiz-Babot G et al. (2021). Defects in the GnRH Neuronal Migration factor, CCDC141, Lead to Self-Limited Delayed Puberty. nameOfConference


  • Mariniello K, Guasti L (2021). Towards novel treatments for adrenal diseases: Cell- and gene therapy-based approaches. nameOfConference


  • Squizzato A, Maroni L, Marrazzo C et al. (2021). Diagnostic accuracy of inferior vena cava ultrasound for heart failure in patients with acute dyspnoea: a systematic review and meta-analysis. nameOfConference


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  • Caspani F, Tralongo AC, Campiotti L et al. (2021). Prevention of anthracycline-induced cardiotoxicity: a systematic review and meta-analysis. nameOfConference


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  • Guasti L, Galliazzo S, Molaro M et al. (2021). TMAO as a biomarker of cardiovascular events: a systematic review and meta-analysis. nameOfConference


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  • Mancini A, Howard SR, Marelli F et al. (2020). LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling. nameOfConference


  • Mariniello K, Rognoni E, Guasti L (2020). SUN-LB43 DLK1 Expressing Cells Contribute to the Zonation of the Adrenal Gland. nameOfConference


  • Mancini A, Howard SR, Cabrera CP et al. (publicationYear). Defects in LGR4 Wnt-[beta]-catenin signalling impair GnRH network development, leading to delayed puberty. nameOfConference


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  • Mariniello K, Ruiz-Babot G, McGaugh EC et al. (publicationYear). Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System. nameOfConference


  • Gualtieri A, Nicholson J, Tan R et al. (publicationYear). Efnb2 controls pituitary gland development by regulating proliferation of the pituitary stem/progenitor cells and EMT within the pituitary stem cell niche. nameOfConference


    QMRO: qmroHref
  • Donati S, Maresca AM, Cattaneo J et al. (2021). Optical coherence tomography angiography and arterial hypertension: A role in identifying subclinical microvascular damage?. nameOfConference


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  • Riva N, Ageno W, Guasti L et al. (2013). Commentary. nameOfConference


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  • A M, SR H, CP C et al. (publicationYear). EAP1 regulation of GnRH promoter activity is important for human pubertal timing. nameOfConference


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  • SR H, R O, A P et al. (publicationYear). HS6ST1 insufficiency causes self-limited delayed puberty in contrast with other GnRH deficiency genes. nameOfConference


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  • Liew S-Y, Akker SA, Guasti L et al. (2019). Glucocorticoid replacement therapies: past, present and future. nameOfConference


  • Hadjidemetriou I, Mariniello K, Ruiz-Babot G et al. (2019). DLK1/PREF1 marks a novel cell population in the human adrenal cortex. nameOfConference


  • Novoselova TV, King PJ, Guasti L et al. (2019). ACTH signalling and adrenal development: lessons from mouse models. nameOfConference


  • Maharaj A, Maudhoo A, Chan LF et al. (2019). Isolated glucocorticoid deficiency: Genetic causes and animal models. nameOfConference


  • Maresca AM, Guasti L, Bozzini S et al. (2019). sRAGE and early signs of cardiac target organ damage in mild hypertensives. nameOfConference


    QMRO: qmroHref
  • Papathomas TG, Sun N, Chortis V et al. (2019). Novel methods in adrenal research: a metabolomics approach. nameOfConference


  • Pittaway JFH, Guasti L (2019). Pathobiology and genetics of adrenocortical carcinoma. nameOfConference


  • Mancini A, Howard SR, Cabrera CP et al. (2019). EAP1 regulation of GnRH promoter activity is important for human pubertal timing. nameOfConference


  • Saengkaew T, Mancini A, Ruiz-Babot G et al. (2019). Defects in the GnRH Neuroendocrine Network Affect the Timing of Puberty. nameOfConference

    DOI: doi

  • Mancini A, Howard SR, Cabrera CP et al. (2019). LGR 4-Wnt β-catenin signalling directs GnRH network development, with defects leading to self-limited delayed puberty. nameOfConference

    DOI: doi

  • Guasti L (2019). Novel interventions to treat adrenal insufficiency. nameOfConference

    DOI: doi

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  • Maharaj A, Buonocore F, Meimaridou E et al. (2019). Predicted Benign and Synonymous Variants in CYP11A1 Cause Primary Adrenal Insufficiency Through Missplicing. nameOfConference


  • Campiotti L, Bolzacchini E, Sutter MB et al. (2018). Vitamin D and tyrosine kinase inhibitors in chronic myeloid leukemia. nameOfConference


    QMRO: qmroHref
  • G R-B, M B, I H et al. (publicationYear). Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells. nameOfConference


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  • De Ferrari GM, Perna GP, Nicosia A et al. (2018). Available oral lipid-lowering agents could bring most high-risk patients to target. nameOfConference


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  • Dentali F, Nigro O, Squizzato A et al. (2018). Impact of neutrophils to lymphocytes ratio on major clinical outcomes in patients with acute coronary syndromes: A systematic review and meta-analysis of the literature. nameOfConference


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  • Mortara L, Gariboldi MB, Bosi A et al. (2018). Vitamin D Deficiency has a Negative Impact on Cetuximab-Mediated Cellular Cytotoxicity against Human Colon Carcinoma Cells. nameOfConference


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  • Guasti L, New SE, Hadjidemetriou I et al. (2018). Plasticity of human adipose-derived stem cells - relevance to tissue repair.. nameOfConference


  • Howard SR, Oleari R, Poliandri A et al. (2018). HS6ST1 Insufficiency Causes Self-Limited Delayed Puberty in Contrast With Other GnRH Deficiency Genes. nameOfConference


  • Novoselova TV, Hussain M, King PJ et al. (2018). MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. nameOfConference


  • Lupi A, Bona RD, Meliga E et al. (2018). Early P2Y12 Inhibitors Escalation in Primary PCI Patients: Insights from the RENOVAMI Registry. nameOfConference


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  • Tamborini Permunian E, Gervaso L, Gerdes V et al. (2018). Direct-acting antiviral drugs for chronic hepatitis C and risk of major vascular events: a systematic review. nameOfConference


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  • Balyura M, Gelfgat E, Steenblock C et al. (2018). Expression of progenitor markers is associated with the functionality of a bioartificial adrenal cortex.. nameOfConference


  • Grazioli S, Paciaroni M, Agnelli G et al. (2018). Cancer-associated ischemic stroke: A retrospective multicentre cohort study. nameOfConference


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  • Galliazzo S, Nigro O, Bertù L et al. (2018). Prognostic role of neutrophils to lymphocytes ratio in patients with acute pulmonary embolism: a systematic review and meta-analysis of the literature. nameOfConference


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  • Ruiz-Babot G, Balyura M, Hadjidemetriou I et al. (2018). Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells. nameOfConference


  • Mancini A, Howard SR, Cabrera CP et al. (2018). EAP1 Mutations Cause an Impaired Transcriptional Activity on GnRH Promoter That Leads to Self-Limited Delayed Puberty. nameOfConference

    DOI: doi

  • Howard S, Oleari R, Mancini A et al. (2018). Role of GnRH Neuronal Migration and Development in Self-Limited Delayed Puberty. nameOfConference

    DOI: doi

  • Dentali F, Gianni M, Mumoli N et al. (2014). Efficacy and safety of patent foramen ovale closure in patients with a cryptogenic stroke: Systematic review and meta-analysis. nameOfConference


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  • Guasti L, Dentali F, Castiglioni L et al. (2011). Neutrophils and clinical outcomes in patients with acute coronary syndromes and/or cardiac revascularisation. nameOfConference


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  • Dentali F, Gianni M, Squizzato A et al. (2011). Use of statins and recurrence of atrial fibrillation after catheter ablation or electrical cardioversion. nameOfConference


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  • Howard SR, Guasti L, Poliandri A et al. (2018). Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty. nameOfConference


  • Howard S, Andre V, Guasti L et al. (publicationYear). Patients with self-limited delayed puberty harbour mutations in multiple genes controlling GnRH neuronal development. nameOfConference


    QMRO: qmroHref
  • Maharaj A, Buonocore F, Meimaridou E et al. (publicationYear). Predicted benign and silent SNPs in CYP11A1 cause primary adrenal insufficiency through missplicing. nameOfConference


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  • Guasti L, Squizzato A, Moretto P et al. (publicationYear). In vitro effects of Apixaban on 5 different cancer cell lines. nameOfConference


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  • Guasti L, Gaudio G, Lupi A et al. (publicationYear). Ambulatory blood pressure parameters after canrenone addition to existing treatment regimens with maximum tolerated dose of angiotensin-converting enzyme inhibitors/angiotensin II type 1 receptor blockers plus hydrochlorothiazide in uncontrolled hypertensive patients. nameOfConference


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  • Donadini MP, Dentali F, Pegoraro S et al. (2017). Long-term recurrence of venous thromboembolism after short-term treatment of symptomatic isolated distal deep vein thrombosis: A cohort study. nameOfConference


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  • Squizzato A, Suter MB, Nerone M et al. (2017). PCSK9 inhibitors for treating dyslipidemia in patients at different cardiovascular risk: a systematic review and a meta-analysis. nameOfConference


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  • Katugampola H, King PJ, Chatterjee S et al. (2017). Kisspeptin is a novel regulator of human fetal adrenocortical development and function – a finding with important implications for the human feto-placental unit. nameOfConference


  • Donadini MP, Dentali F, Castellaneta M et al. (2017). Pulmonary embolism prognostic factors and length of hospital stay: A cohort study. nameOfConference


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  • Squizzato A, Pomero F, Allione A et al. (2017). Diagnostic accuracy of magnetic resonance imaging in patients with suspected pulmonary embolism: A bivariate meta-analysis. nameOfConference


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  • Campiotti L, Suter MB, Guasti L et al. (2017). Imatinib discontinuation in chronic myeloid leukaemia patients with undetectable BCR-ABL transcript level: A systematic review and a meta-analysis. nameOfConference


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  • Tufton N, Roncaroli F, Hadjudemetriou I et al. (publicationYear). Metastatic pituitary carcinoma in an SDHB mutation positive patient. nameOfConference


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  • Tufton N, Roncaroli F, Hadjidemetriou I et al. (2017). Pituitary Carcinoma in a Patient with an SDHB Mutation.. nameOfConference


  • Poliandri A, Miller D, Howard S et al. (2017). Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells. nameOfConference


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  • METHERELL LA, Prasad R, Storr HL et al. (2017). Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. nameOfConference


  • Roncaroli F, Tufton N, Hadjidemetriou I et al. (2017). Pituitary carcinoma in a patient with germline Succinate Dehydrogenase B mutation. 118th Meeting of the British-Neuropathological-Society


  • Howard SR, Andre V, Guasti L et al. (2017). DISCOVERY OF MUTATIONS IN MULTIPLE GENES CONTROLLING GNRH NEURONAL MIGRATION AND DEVELOPMENT IN PATIENTS WITH SELF-LIMITED DELAYED PUBERTY. nameOfConference

    DOI: doi

  • Mistry JN, Ruiz-Babot G, Zaman F et al. (2017). MECHANISMS OF FIBROBLAST GROWTH FACTOR 21 (FGF21) MEDIATED GROWTH HORMONE RESISTANCE IN HUMAN GROWTH PLATE IN CHRONIC CHILDHOOD CONDITIONS. nameOfConference

    DOI: doi

  • Derosa G, Maffioli P, D'Avino M et al. (2017). Efficacy and safety of two dosages of canrenone as add‐on therapy in hypertensive patients taking ace‐inhibitors or angiotensin II receptor blockers and hydrochlorothiazide at maximum dosage in a randomized clinical trial: The ESCAPE‐IT trial. nameOfConference


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  • GUASTI L (2016). Towards reconstruction of epithelialized cartilages from autologous adipose tissue-derived stem cells. nameOfConference


  • Ruiz-Babot G, Hadjidemetriou I, Ajodha SJ et al. (publicationYear). Generation of human urine-derived steroidogenic cells through lineage conversion: A new technology to study the adrenal gland. nameOfConference


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  • Mancini A, Howard SR, Ruiz-Babot G et al. (publicationYear). LGR4 and EAP1 mutations are implicated in the phenotype of self-limited delayed puberty. nameOfConference


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  • METHERELL LA (2016). Mutations in SGPL1, encoding sphingosine-1-phosphate lyase, cause a novel form of primary adrenal insufficiency with steroid resistant nephrotic syndrome. Society for Endocrinology BES 2016


  • Narendra MJ, Ruiz-Babot G, Guasti L et al. (publicationYear). The mechanistic role of fibroblast growth factor 21 in growth hormone resistance secondary to chronic childhood conditions. nameOfConference


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  • Novoselova TV, Larder R, Rimmington D et al. (publicationYear). Loss of Mrap2 is associated with Sim 1 deficiency and increased circulating cholesterol. nameOfConference


  • HOWARD SR, Guasti L, Ruiz-Babot G et al. (2016). IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty. nameOfConference


  • Dentali F, Conte G, Guasti L (2016). Neutrophil-to-lymphocyte ratio: a new prognostic factor even in patients with heart failure.. nameOfConference


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  • Howard S, Guasti L, Ruiz-Babot G et al. (2016). Role of IGSF10 mutations in self-limited delayed puberty. nameOfConference


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  • Guasti L, Maresca AM, Schembri L et al. (2016). Relationship between regulatory T cells subsets and lipid profile in dyslipidemic patients: a longitudinal study during atorvastatin treatment. nameOfConference


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  • Howard S, Poliandre A, Storr HL et al. (publicationYear). Mutations in HS6ST1 cause self-limited delayed puberty (DP) in addition to idiopathic hypogonadotropic hypogonadism (IHH). nameOfConference


    QMRO: qmroHref
  • Howard S, Guasti L, Ruiz-Babot G et al. (publicationYear). Mutations in IGSF10 cause self-limited delayed puberty. nameOfConference


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  • Babot GR, Hadjidemetriou I, Ajodha SJ et al. (publicationYear). Lineage conversion of human cells to an adrenocortical phenotype: a new technology to study the adrenal gland. nameOfConference


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  • Howard S, Poliandri A, Storr H et al. (publicationYear). Mutations in HS6ST1 are causal in self-limited delayed puberty as well as idiopathic hypogonadotropic hypogonadism. nameOfConference


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  • Howard S, Guasti L, Ruiz-Babot G et al. (publicationYear). Mutations in IGSF10 cause self-limited delayed puberty, via disturbance of GnRH neuronal migration. nameOfConference


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  • Hadjidemetriou I, Ruiz-Babot G, Gomez-Sanchez C et al. (publicationYear). Unveiling the complexity of the undifferentiated zone in the human adrenal cortex. nameOfConference


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  • Dentali F, Sironi AP, Gianni M et al. (2015). Gender Difference in Efficacy and Safety of Nonvitamin K Antagonist Oral Anticoagulants in Patients with Nonvalvular Atrial Fibrillation or Venous Thromboembolism: A Systematic Review and a Meta-Analysis of the Literature. nameOfConference


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  • Ruiz-Babot G, Hadjidemetriou I, King PJ et al. (publicationYear). New Directions for the Treatment of Adrenal Insufficiency. nameOfConference


  • Specchia G, Falcone C, Tortorici M et al. (1990). Silent Ischemia during PTCA: Its Relationship with Exercise-Induced Silent Ischemia and the Possible Role for Beta-Endorphins. nameOfConference


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  • Permunian ET, Riva N, Guasti L et al. (2015). Cangrelor for the treatment of arterial thrombosis: pharmacokinetics/pharmacodynamics and clinical data. nameOfConference


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  • Galli L, Gerdes VEA, Guasti L et al. (2014). Thrombosis Associated with Viral Hepatitis. nameOfConference


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  • Guasti L, Silvennoinen S, Bulstrode NW et al. (2014). Elevated FGF21 leads to attenuated postnatal linear growth in preterm infants through GH resistance in chondrocytes.. nameOfConference


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  • Katugampola H, Halder W, Ganatra R et al. (publicationYear). Expression of Sonic hedgehog signalling components in the developing human adrenal cortex. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Nicolini E, Rizzi L et al. (2014). Dyslipidemia in HIV‐positive patients: a randomized, controlled, prospective study on ezetimibe+fenofibrate versus pravastatin monotherapy. nameOfConference


    QMRO: qmroHref
  • Donadini MP, Dentali F, Squizzato A et al. (2014). Unsuspected pulmonary embolism in cancer patients: a narrative review with pooled data. nameOfConference


    QMRO: qmroHref
  • Marino F, Maresca AM, Castiglioni L et al. (2014). Simvastatin down-regulates the production of Interleukin-8 by neutrophil leukocytes from dyslipidemic patients. nameOfConference


    QMRO: qmroHref
  • Ferrari M, Guasti L, Maresca A et al. (2014). Association between statin-induced creatine kinase elevation and genetic polymorphisms in SLCO1B1, ABCB1 and ABCG2. nameOfConference


    QMRO: qmroHref
  • Howard S, Guasti L, Storr H et al. (publicationYear). A novel gene affecting the timing of puberty. nameOfConference


    QMRO: qmroHref
  • Campiotti L, Maresca A, Guasti L et al. (2014). Tirosine Kinase Inhibitors Adverse Events. nameOfConference


    QMRO: qmroHref
  • Guasti L, Vagaska B, Bulstrode NW et al. (2014). Chondrogenic differentiation of adipose tissue-derived stem cells within nanocaged POSS-PCU scaffolds: a new tool for nanomedicine.. nameOfConference


    QMRO: qmroHref
  • Falcone C, Matrone B, Bozzini S et al. (2014). Time-Domain Heart Rate Variability in Coronary Artery Disease Patients Affected by Thyroid Dysfunction. nameOfConference


    QMRO: qmroHref
  • Bozzato S, Squizzato A, Donadini MP et al. (2013). Patient selection for thromboprophylaxis in medical inpatients. nameOfConference


    QMRO: qmroHref
  • Dentali F, Riva N, Turato S et al. (2013). Pulmonary embolism severity index accurately predicts long‐term mortality rate in patients hospitalized for acute pulmonary embolism. nameOfConference


    QMRO: qmroHref
  • Falcone C, Bozzini S, Guasti L et al. (2013). Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease. nameOfConference


    QMRO: qmroHref
  • Guasti L, Cavlan D, Cogger K et al. (2013). Dlk1 upregulates Gli1 expression in male rat adrenal capsule cells through the activation of β1 integrin and ERK1-2.. nameOfConference


    QMRO: qmroHref
  • Squizzato A, Rancan E, Dentali F et al. (2013). Diagnostic accuracy of lung ultrasound for pulmonary embolism: a systematic review and meta‐analysis. nameOfConference


    QMRO: qmroHref
  • Guasti L, Candy Sze WC, McKay T et al. (2013). FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development.. nameOfConference


  • Meimaridou E, Hughes CR, Kowalczyk J et al. (2013). Familial glucocorticoid deficiency: New genes and mechanisms. nameOfConference


    QMRO: qmroHref
  • Meimaridou E, Hughes CR, Kowalczyk J et al. (2013). Familial glucocorticoid deficiency: New genes and mechanisms.. nameOfConference


    QMRO: qmroHref
  • Donadini MP, Ageno W, Guasti L et al. (2013). Certoparin for the treatment and prevention of thrombosis: pharmacological profile and results from clinical studies. nameOfConference


    QMRO: qmroHref
  • Marino F, Guasti L, Tozzi M et al. (2013). Gene Expression of Adhesion Molecules in Endothelial Cells from Patients with Peripheral Arterial Disease Is Reduced after Surgical Revascularization and Pharmacological Treatment. nameOfConference


    QMRO: qmroHref
  • Yates R, Katugampola H, Cavlan D et al. (2013). Adrenocortical development, maintenance, and disease.. nameOfConference


    QMRO: qmroHref
  • Marino F, Maresca AM, Cosentino M et al. (2012). Angiotensin II type 1 and type 2 receptor expression in circulating monocytes of diabetic and hypercholesterolemic patients over 3-month rosuvastatin treatment. nameOfConference


    QMRO: qmroHref
  • Cogger K, Guasti L, Ashworth R et al. (2012). The role of primary cilia in mouse adrenal and zebrafish interrenal development. nameOfConference


    QMRO: qmroHref
  • Squizzato A, Guasti L, Ageno W (2012). Statins are better than fibrates in patients with a previous venous thromboembolism. nameOfConference


    QMRO: qmroHref
  • Kowalczyk⁎ J, Meimaridou E, Guasti L et al. (2012). A homozygous glutathione peroxidase 1 mutation, p. Arg130-Leu133del, in a patient with familial glucocorticoid deficiency. nameOfConference


    QMRO: qmroHref
  • Nicolini E, Martegani G, Maresca AM et al. (2013). Left ventricular remodeling in patients with metabolic syndrome: Influence of gender. nameOfConference


    QMRO: qmroHref
  • Meimaridou E, Kowalczyk J, Guasti L et al. (2012). Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency.. nameOfConference


  • Guasti L, Prasongchean W, Kleftouris G et al. (2012). High plasticity of pediatric adipose-derived stem cells: too much for selective skeletogenic differentiation?. nameOfConference


    QMRO: qmroHref
  • Hughes CR, Guasti L, Meimaridou E et al. (2012). MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans. nameOfConference


    QMRO: qmroHref
  • Marchesi C, Dentali F, Nicolini E et al. (2012). Plasma levels of matrix metalloproteinases and their inhibitors in hypertension. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Laurita E, Marchesi C et al. (2012). OSA, metabolic syndrome and CPAP: Effect on cardiac remodeling in subjects with abdominal obesity. nameOfConference


    QMRO: qmroHref
  • Maroni L, Guasti L, Castiglioni L et al. (2011). Lipid Targets During Statin Treatment in Dyslipidemic Patients Affected by Nonalcoholic Fatty Liver Disease. nameOfConference


    QMRO: qmroHref
  • Cooray SN, Guasti L, Clark AJL (2011). The E3 ubiquitin ligase Mahogunin ubiquitinates the melanocortin 2 receptor.. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Nicolini E, Giola M et al. (2012). Left ventricular remodelling in asymptomatic HIV infection on chronic HAART: comparison between hypertensive and normotensive subjects with and without HIV infection. nameOfConference


    QMRO: qmroHref
  • Gorrigan RJ, Guasti L, King P et al. (2011). Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland.. nameOfConference


  • Guasti L, Paul A, Laufer E et al. (2011). Localization of Sonic hedgehog secreting and receiving cells in the developing and adult rat adrenal cortex.. nameOfConference


    QMRO: qmroHref
  • Dentali F, Guasti L (2010). Are Statins Effective in High-Risk Primary Prevention?. nameOfConference


    QMRO: qmroHref
  • Igreja S, Chahal HS, King P et al. (2010). Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families.. nameOfConference


  • Guasti L, Marino F, Congiu T et al. (2010). Laminar Pattern of Mineral Calcium-Phosphorus Deposits in a Human Carotid Plaque. nameOfConference


    QMRO: qmroHref
  • Congiu T, Schembri L, Tozzi M et al. (2010). Scanning electron microscopy examination of endothelium morphology in human carotid plaques. nameOfConference


    QMRO: qmroHref
  • Squizzato A, Galli M, Romualdi E et al. (2010). Statins, fibrates, and venous thromboembolism: a meta-analysis. nameOfConference


    QMRO: qmroHref
  • Marino F, Guasti L, Tozzi M et al. (2009). Angiotensin Type 1 Receptor Expression and Interleukin-8 Production in Polymorphonuclear Leukocytes of Patients With Peripheral Arterial Disease. nameOfConference


    QMRO: qmroHref
  • Guasti L, Marino F, Cosentino M et al. (2011). Cytokine production from peripheral blood mononuclear cells and polymorphonuclear leukocytes in patients studied for suspected obstructive sleep apnea. nameOfConference


    QMRO: qmroHref
  • Guasti L, Mainardi LT, Baselli G et al. (2010). Components of arterial systolic pressure and RR-interval oscillation spectra in a case of baroreflex failure, a human open-loop model of vascular control. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Solbiati F, Laurita E et al. (2005). Isolated office hypertension: A 3‐year follow‐up study. nameOfConference


    QMRO: qmroHref
  • Guasti L, Richardson D, Jhaveri M et al. (2009). Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain.. nameOfConference


  • Chan LF, Webb TR, Chung T-T et al. (2009). MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Bignotti M, Bertolini A et al. (1997). Clinical Feasibility of Echocardiographic Automated Border Detection in Monitoring Left Ventricular Response to Acute Changes of Preload in Normal Subjects. nameOfConference


    QMRO: qmroHref
  • Guasti L, Simoni C, Mainardi L et al. (2009). Lack of relationship between cardiovascular reactivity to mental stress and autonomic modulation of the sinoatrial node in normotensive and hypertensive male subjects. nameOfConference


    QMRO: qmroHref
  • Pessia M, Servettini I, Panichi R et al. (2008). ERG voltage-gated K+ channels regulate excitability and discharge dynamics of the medial vestibular nucleus neurones. nameOfConference


    QMRO: qmroHref
  • King PJ, Guasti L, Laufer E (2008). Hedgehog signalling in endocrine development and disease. nameOfConference


    QMRO: qmroHref
  • Guasti L, Crociani O, Redaelli E et al. (2008). Identification of a posttranslational mechanism for the regulation of hERG1 K+ channel expression and hERG1 current density in tumor cells.. nameOfConference


    QMRO: qmroHref
  • Schembri L, Congiu T, Tozzi M et al. (2008). Scanning Electron Microscopy Examination and Elemental Analysis of Atherosclerotic Calcifications in a Human Carotid Plaque. nameOfConference


    QMRO: qmroHref
  • Marino F, Guasti L, Cosentino M et al. (2008). Simvastatin treatment in subjects at high cardiovascular risk modulates AT1R expression on circulating monocytes and T lymphocytes. nameOfConference


    QMRO: qmroHref
  • Guasti L, Marino F, Cosentino M et al. (2008). Prolonged statin-associated reduction in neutrophil reactive oxygen species and angiotensin II type 1 receptor expression: 1-year follow-up. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Solbiati F, Laurita E et al. (2008). Effects of Dual Blockade of Renin–Angiotensin System on Concentric Left Ventricular Hypertrophy in Essential Hypertension: a Randomized, Controlled Pilot Study. nameOfConference


    QMRO: qmroHref
  • Marchesi C, Maresca AM, Solbiati F et al. (2007). Masked Hypertension in Type 2 Diabetes Mellitus. nameOfConference


    QMRO: qmroHref
  • Guasti L, Marino F, Cosentino M et al. (2007). Pain Perception, Blood Pressure Levels, and Peripheral Benzodiazepine Receptors in Patients Followed for Differentiated Thyroid Carcinoma: A Longitudinal Study in Hypothyroidism and During Hormone Treatment. nameOfConference


    QMRO: qmroHref
  • Marino F, Guasti L, Cosentino M et al. (2007). Angiotensin II Type 1 Receptor Expression in Polymorphonuclear Leukocytes From High-Risk Subjects: Changes After Treatment With Simvastatin. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Laurita E, Marchesi C et al. (2007). Family History of Hypertension Influences Left Ventricular Diastolic Function During Chronic Antihypertensive Therapy. nameOfConference


    QMRO: qmroHref
  • Guasti L, Simoni C, Scamoni C et al. (2007). An unusual case presenting with hypertensive crisis. nameOfConference


    QMRO: qmroHref
  • Furlan F, Taccola G, Grandolfo M et al. (2007). ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord. nameOfConference


    QMRO: qmroHref
  • Guasti L, Marino F, Cosentino M et al. (2006). Simvastatin treatment modifies polymorphonuclear leukocyte function in high-risk individuals: a longitudinal study. nameOfConference


    QMRO: qmroHref
  • Guasti L, Marino F, Cosentino M et al. (2007). Changes in Autonomic Modulation to the Heart and Intracellular Catecholamines. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Laurita E, Solbiati F et al. (2006). Angiotensin-converting Enzyme Inhibitors Influence Left Ventricular Mass and Function Independently of the Antihypertensive Effect. nameOfConference


    QMRO: qmroHref
  • Guasti L, Simoni C, Scamoni C et al. (2006). Mixed cranial nerve neuroma revealing itself as baroreflex failure. nameOfConference


    QMRO: qmroHref
  • Restano R, Korolkova Y, Diochot S et al. (2006). Species diversity and peptide toxin blocking selectively of ERG subfamily K+ channels in the central nervous system.. nameOfConference


    QMRO: qmroHref
  • Rasini E, Cosentino M, Marino F et al. (2006). Angiotensin II type 1 receptor expression on human leukocyte subsets: A flow cytometric and RT-PCR study. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Maresca AM, Giudici E et al. (2006). Metabolic Syndrome and Morphofunctional Characteristics of the Left Ventricle in Clinically Hypertensive Nondiabetic Subjects. nameOfConference


    QMRO: qmroHref
  • Marino F, Guasti L, Cosentino M et al. (2006). Thyroid hormone and thyrotropin regulate intracellular free calcium concentrations in human polymorphonuclear leukocytes: in vivo and in vitro studies.. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Piantanida E, Franzetti I et al. (2006). Effect of Glycemic Control on Left Ventricular Diastolic Function in Type 1 Diabetes Mellitus. nameOfConference


    QMRO: qmroHref
  • Guasti L, Cilia E, Crociani O et al. (2005). Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits.. nameOfConference


    QMRO: qmroHref
  • Marino F, Guasti L, Cosentino M et al. (2006). Thyroid hormone regulation of cell migration and oxidative metabolism in polymorphonuclear leukocytes: Clinical evidence in thyroidectomized subjects on thyroxine replacement therapy. nameOfConference


    QMRO: qmroHref
  • Guasti L, Simoni C, Mainardi LT et al. (2005). Circadian blood pressure variability is associated with autonomic and baroreflex-mediated modulation of the sinoatrial node. nameOfConference


    QMRO: qmroHref
  • Guasti L, Simoni C, Mainardi L et al. (2005). Global link between heart rate and blood pressure oscillations at rest and during mental arousal in normotensive and hypertensive subjects. nameOfConference


    QMRO: qmroHref
  • Cherubini A, Hofmann G, Pillozzi S et al. (2005). Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling.. nameOfConference


    QMRO: qmroHref
  • Gaudio G, Guasti L, Schizzarotto A et al. (2005). Changes in Plasma Lipids During Renin-Angiotensin System Blockade by Combination Therapy (Enalapril Plus Valsartan) in Patients With Diabetes and Hypertension. nameOfConference


    QMRO: qmroHref
  • Furlan* F, Guasti* L, Avossa D et al. (2005). Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro. nameOfConference


    QMRO: qmroHref
  • Arcangeli A, Becchetti A, Cherubini A et al. (2004). Physical and functional interaction between integrins and hERG potassium channels. nameOfConference


    QMRO: qmroHref
  • Arcangeli A, Becchetti A, Cherubini A et al. (2004). Physical and functional interaction between integrins and hERG potassium channels.. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Laurita E, Selva E et al. (2004). Natriuretic peptides as markers of preclinical cardiac disease in obesity. nameOfConference


    QMRO: qmroHref
  • Lastraioli* E, Guasti* L, Crociani O et al. (2004). herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells.. nameOfConference


    QMRO: qmroHref
  • GRANDI AM, GAUDIO G, FACHINETTI A et al. (1997). Influence of family history of hypertension on insulin sensitivity in lean and obese hypertensive subjects. nameOfConference


    QMRO: qmroHref
  • Crociani O, Guasti L, Balzi M et al. (2003). Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells.. nameOfConference


    QMRO: qmroHref
  • Gullo F, Ales E, Rosati B et al. (2003). ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2‐related sudden death?. nameOfConference


  • Grandi AM, Imperiale D, Santillo R et al. (2002). Aldosterone Antagonist Improves Diastolic Function in Essential Hypertension. nameOfConference


    QMRO: qmroHref
  • Pillozzi S, Brizzi MF, Balzi M et al. (2002). HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors.. nameOfConference


    QMRO: qmroHref
  • Guasti L, Zanotta D, Mainardi LT et al. (2002). Hypertension-related hypoalgesia, autonomic function and spontaneous baroreflex sensitivity. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Broggi R, Jessula A et al. (2002). Relation of extent of nocturnal blood pressure decrease to cardiovascular remodeling in never-treated patients with essential hypertension. nameOfConference


    QMRO: qmroHref
  • Guasti L, Zanotta D, Diolisi A et al. (2002). Changes in pain perception during treatment with angiotensin converting enzyme-inhibitors and angiotensin II type 1 receptor blockade. nameOfConference


    QMRO: qmroHref
  • Cherubini A, Pillozzi S, Hofmann G et al. (2002). HERG K+ channels and β1 integrins interact through the assembly of a macromolecular complex. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Broggi R, Colombo S et al. (2001). Left Ventricular Changes in Isolated Office Hypertension: A Blood Pressure–Matched Comparison With Normotension and Sustained Hypertension. nameOfConference


    QMRO: qmroHref
  • Guasti L, Petrozzino MR, Mainardi LT et al. (2001). Autonomic function and baroreflex sensitivity during angiotensin-converting enzyme inhibition or angiotensin II AT-1 receptor blockade in essential hypertensive patients. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Zanzi P, Broggi R et al. (2001). Longitudinal Changes of Insulin Sensitivity in Essential Hypertension: Influence of Blood Pressure Control and Familial Predisposition to Hypertension. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Santillo R, Bertolini A et al. (2001). Microalbuminuria as a marker of preclinical diastolic dysfunction in never-treated essential hypertensives. nameOfConference


    QMRO: qmroHref
  • Hofmann G, Bernabei PA, Crociani O et al. (2001). HERG K channels activation during β1 integrin-mediated adhesion to fibronectin induces an up regulation of αvβ3 integrin in the preosteoclastic leukemia cell line.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hofmann G, Bernabei PA, Crociani O et al. (2001). HERG K+ Channels Activation during β1Integrin-mediated Adhesion to Fibronectin Induces an Up-regulation of αvβ3 Integrin in the Preosteoclastic Leukemia Cell Line FLG 29.1*. nameOfConference


    QMRO: qmroHref
  • Grandi A, Zanzi P, Piantanida E et al. (2000). Obesity and left ventricular diastolic function: noninvasive study in normotensives and newly diagnosed never-treated hypertensives. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Santillo R, Zanzi P et al. (2000). Microalbuminuria in never-treated hypertensives: Lack of relationship to hyperinsulinemia and genetic predisposition to hypertension. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Zanzi P, Fachinetti A et al. (1999). Insulin and Diastolic Dysfunction in Lean and Obese Hypertensives. nameOfConference


    QMRO: qmroHref
  • Guasti L, Zanotta D, Petrozzino MR et al. (1999). Relationship between dental pain perception and 24 hour ambulatory blood pressure. nameOfConference


    QMRO: qmroHref
  • Guasti L, Gaudio G, Zanotta D et al. (1999). Relationship between a genetic predisposition to hypertension, blood pressure levels and pain sensitivity. nameOfConference


    QMRO: qmroHref
  • Guasti L, Grimoldi P, Mainardi LT et al. (1999). Autonomic function and baroreflex sensitivity during a normal ovulatory cycle in humans.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Grandi AM, Broggi R, Zanzi P et al. (1999). Individualized versus standardized analysis of ambulatory blood pressure profile: relationship with left ventricular characteristics. nameOfConference


    QMRO: qmroHref
  • Guasti L, Diolisi A, Gaudio G et al. (1998). Reactivity of blood pressure to mental arithmetic stress test, stress-test recovery time, and ambulatory blood pressure in hypertensive and normotensive subjects.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Grandi A, Gaudio G, Fachinetti A et al. (1998). Insulin sensitivity in obese normotensive adults: influence of family history of hypertension. nameOfConference


    QMRO: qmroHref
  • Guasti L, Grimoldi P, Diolisi A et al. (1998). Treatment With Enalapril Modifies the Pain Perception Pattern in Hypertensive Patients. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Zanzi P, Ceriani L et al. (1997). Relationship Between Left Ventricular Diastolic Function and Atrial Natriuretic Factor in Never-Treated Mild Hypertensives. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Pinotti G, Morandi E et al. (1997). Noninvasive evaluation of cardiotoxicity of 5-fluorouracil and low doses of folinic acid: A one-year follow-up study. nameOfConference


    QMRO: qmroHref
  • Guasti L, Grimoldi P, Ceriani L et al. (1997). Atrial natriuretic peptide and 24 h blood pressure.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Guasti L, Marino F, Gaudio G et al. (1997). Ambulatory blood pressure, nocturnal blood pressure reduction and plasma catecholamines.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Guasti L, Cattaneo R, Daneri A et al. (1996). Endogenous beta-endorphins in hypertension: Correlation with 24-hour ambulatory blood pressure. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Gaudio G, Fachinetti A et al. (1996). Hyperinsulinemia, Family History of Hypertension, and Essential Hypertension. nameOfConference


    QMRO: qmroHref
  • Bossi PM, Guasti L, Merlo B et al. (1995). Effects of arithmetic mental stress test on hypertension-related hypalgesia. nameOfConference


    QMRO: qmroHref
  • Grandi AM, Bignotti M, Gaudio G et al. (1995). Ambulatory Blood Pressure and Left Ventricular Changes During Antihypertensive Treatment. nameOfConference


    QMRO: qmroHref
  • Guasti L, Cattaneo R, Rinaldi O et al. (1995). Twenty-four-hour noninvasive blood pressure monitoring and pain perception.. nameOfConference


    QMRO: qmroHref
  • Bignotti M, Grandi AM, Gaudio G et al. (1995). One-year antihypertensive treatment with amlodipine: effects on 24-hour blood pressure and left ventricular anatomy and function.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Falcone C, Guasti L, Ochan M et al. (1993). Beta-endorphins during coronary angioplasty in patients with silent or symptomatic myocardial ischemia. nameOfConference


    QMRO: qmroHref
  • Specchia G, Falcone C, Traversi E et al. (1991). Mental stress as a provocative test in patients with various clinical syndromes of coronary heart disease.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Salerno JA, Guasti L, Panciroli C et al. (1990). Syncope and sudden death due to vasospastic myocardial ischemia in young sportmen.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Costantini M, Chimienti M, Zardini M et al. (1989). An electrophysiologic and electropharmacological study of functional properties of the bundle of Kent in Wolff-Parkinson-White syndrome.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Falcone C, Sconocchia R, Guasti L et al. (1988). Dental pain threshold and angina pectoris in patients with coronary artery disease. nameOfConference


    QMRO: qmroHref
  • Klersy C, Marangoni E, Salerno JA et al. (1988). Intravenous flecainide in Wolff-Parkinson-White syndrome: a test for evaluation of the refractory period of the anomalous pathway. Comparison with ajmaline.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Falcone C, Specchia G, Rondanelli R et al. (1988). Correlation between beta-endorphin plasma levels and anginal symptoms in patients with coronary artery disease. nameOfConference


    QMRO: qmroHref
  • Salerno JA, Klersy C, Minzioni G et al. (1988). Therapy of arrhythmia by ablation technics with catheters and with surgical technics.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Salerno JA, Klersy C, Chimienti M et al. (1987). Paroxysmal ventricular tachycardias.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • CHIMIENTI M, MOIZI M, SALERNO JA et al. (1987). Electrophysiologic and clinical effects of intravenous and oral encainide in patients with Wolff-Parkinson-White syndrome and paroxysmal atrial fibrillation. nameOfConference


    QMRO: qmroHref
  • Chimienti M, Moizi M, Klersy C et al. (1987). A modified ajmaline test for prediction of the effective refractory period of the accessory pathway in the wolff-parkinson-white syndrome. nameOfConference


    QMRO: qmroHref
  • Salerno JA, Previtali M, Panciroli C et al. (1986). Ventricular arrhythmias during acute myocardial ischaemia in man. The role and significance of R-ST-T alternans and the prevention of ischaemic sudden death by medical treatment.. nameOfConference

    DOI: doi

    QMRO: qmroHref

Sponsors

Collaborators

Internal (Adrenal theme)

Internal (Biology of pubertal timing theme)

External (Adrenal theme)

  • Prof Stefan Bornstein (Technical University of Dresden, Germany/Kings College London, UK)
  • Dr Gerard Ruiz-Babot (Technical University of Dresden, Germany)
  • Prof Celso Gomez-Sanchez (University of Mississippi, USA)
  • Dr Olivia Crociani (University of Florence, Italy)
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