Dr Mathieu-Benoit Voisin

Profile

ORCID iD: 0000-0003-3001-0894

Mathieu-Benoit Voisin graduated in 2000 from the University of Bordeaux II (France) in Biological Sciences with a specialisation in Immunology. He obtained his PhD from the University of Tours (France) in 2003 and conducted post-doctoral research at Imperial College London. In 2007, he relocated with Prof Nourshargh to the William Harvey Research Institute to investigate the mechanisms of leukocyte diapedesis through blood vessels, developing new imaging techniques to visualise the responses. His work lead him to receive the Werner Risau New Investigator Award in Vascular Biology in 2010. In 2012 he was the recipient of the prestigious Versus Arthritis Career Development Fellowship to establish his own independent research programme studying neutrophil migration and functions in the lymphatic & lymphoid system.

Since 2017, Dr Voisin is a Principal Investigator and Senior Lecturer in Immunology at the Centre for Microvascular Research. 

Research

Group members

Researcher/Staff: Dr Jonathon Alexis Coates; Ms Julia Dielesen (PhD Student)

Summary

Publications

• Rolas L, Stein M, Barkaway A et al. (2024). Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues. nameOfConference

  
  

  DOI: 10.1038/s44319-024-00182-x

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98188
• Caxaria S, Bharde S, Fuller AM et al. (2023). Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia. nameOfConference

  
  

  DOI: 10.1073/pnas.2211631120

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86231
• Joulia R, Guerrero-Fonseca IM, Girbl T et al. (publicationYear). Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A. nameOfConference

  
  

  DOI: 10.1038/s41467-022-34695-7

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/82420
• Iqbal AJ, Krautter F, Blacksell IA et al. (2022). Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner. nameOfConference

  
  

  DOI: 10.1096/fj.202100832r

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/76220
• Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A et al. (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. nameOfConference

  
  

  DOI: 10.1016/j.immuni.2021.07.012

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/74480
• Barkaway A, Rolas L, Joulia R et al. (2021). Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. nameOfConference

  
  

  DOI: 10.1016/j.immuni.2021.04.025

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/72327
• Topping LM, Thomas BL, Rhys HI et al. (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. nameOfConference

  
  

  DOI: 10.3389/fimmu.2020.00010

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/63161
• Owen-Woods C, Joulia R, Barkaway A et al. (2020). Local microvascular leakage promotes trafficking of activated neutrophils to remote organs. nameOfConference

  
  

  DOI: 10.1172/JCI133661

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/62838
• Arokiasamy S, King R, Boulaghrasse H et al. (2019). Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo. nameOfConference

  
  

  DOI: 10.3389/fimmu.2019.02316

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/60002
• VOISIN M, leoni G, WOODFIN A et al. (2019). Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. nameOfConference

  
  

  DOI: 10.1002/path.5234

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/54857
• Voisin M, Nourshargh S (2019). Neutrophil trafficking to lymphoid tissues: physiological and pathological implications. nameOfConference

  
  

  DOI: 10.1002/path.5227

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/54509
• GIRBL T, Lenn T, Perez L et al. (publicationYear). Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis. nameOfConference

  
  

  DOI: 10.1016/j.immuni.2018.09.018

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/50484
• Macdougall CE, Wood EG, Loschko J et al. (2018). Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. nameOfConference

  
  

  DOI: 10.1016/j.cmet.2018.02.007

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/36587
• Arokiasamy S, Nourshargh S, Wang W et al. (2017). Characterisation of the lymphatic endothelium glycocalyx and its regulation during acute inflammation in vivo. NA

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Barkaway A, Rolas L, Morrell S et al. (2017). Aged Vasculature Supports Enhanced and Aberrant Neutrophil-Vessel Wall Interactions in vivo. 2nd Joint Meeting of the European-Society-for-Microcirculation (ESM) and European-Vascular-Biology-Organisation (EVBO)

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• King R, Morrell S, Nedospasov S et al. (2017). An Investigation Into the Role of Neutrophil-Derived TNF in Pathophysiological Microvascular Hyperpermeability. 2nd Joint Meeting of the European-Society-for-Microcirculation (ESM) and European-Vascular-Biology-Organisation (EVBO)

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Voisin MB (2017). TNF-alpha drives the migration and crawling of neutrophils into afferent lymphatic vessels during antigen challenge in vivo. 51st Annual Scientific Meeting of the European Society for Clinical Investigation

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• VOISIN M (2017). Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation. nameOfConference

  
  

  DOI: 10.1038/srep44189

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/23723
• Herrera C, Voisin M-B, Escalante T et al. (2016). Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle.. nameOfConference

  
  

  DOI: 10.1371/journal.pone.0168643

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18945
• Pickworth CM, Beal R, Reglero N et al. (2016). Microvascular endothelial cells can exhibit autophagy in vivo: Role in neutrophil transendothelial cell migration?. Experimental Biology Meeting

  
  

  DOI: 10.1096/fasebj.30.1_supplement.165.8

  
  

  QMRO: qmroHref
• Schnoor M, Alcaide P, Voisin M-B et al. (2016). Recruitment of Immune Cells into Inflamed Tissues: Consequences for Endothelial Barrier Integrity and Tissue Functionality. nameOfConference

  
  

  DOI: 10.1155/2016/1561368

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18621
• Woodfin A, Beyrau M, Voisin M-B et al. (2016). ICAM-1–expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia. nameOfConference

  
  

  DOI: 10.1182/blood-2015-08-664995

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/13894
• Schnoor M, Alcaide P, Voisin M-B et al. (2015). Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation. nameOfConference

  
  

  DOI: 10.1155/2015/946509

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18513
• Herrera C, Escalante T, Voisin M-B et al. (publicationYear). Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage. nameOfConference

  
  

  DOI: 10.1371/journal.pntd.0003731

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/9775
• Finsterbusch M, Voisin M-B, Beyrau M et al. (2014). Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF.. nameOfConference

  
  

  DOI: 10.1084/jem.20132413

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/13892
• Colom B, Bodkin J, Voisin MB et al. (2013). Junctional adhesion molecule (JAM)-C can be cleaved by neutrophil elastase at sites of inflammation in vivo. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Voisin M-B, Nourshargh S (2013). Neutrophil transmigration: emergence of an adhesive cascade within venular walls.. nameOfConference

  
  

  DOI: 10.1159/000346659

  
  

  QMRO: qmroHref
• Proebstl D, Voisin M-B, Woodfin A et al. (2012). Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.. nameOfConference

  
  

  DOI: 10.1084/jem.20111622

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/14750
• Woodfin A, Voisin M-B, Beyrau M et al. (2011). The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.. nameOfConference

  
  

  DOI: 10.1038/ni.2062

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19663
• Leoni G, Voisin M-B, Carlson K et al. (2010). The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature.. nameOfConference

  
  

  DOI: 10.1111/j.1476-5381.2010.00688.x

  
  

  QMRO: qmroHref
• Woodfin A, Voisin M-B, Colom B et al. (2010). An investigation into the profile and dynamics of neutrophil transendothelial cell migration (TEM) using high resolution in vivo real-time confocal imaging. nameOfConference

  
  

  DOI: 10.1096/fasebj.24.1_supplement.232.2

  
  

  QMRO: qmroHref
• Woodfin A, Voisin M-B, Nourshargh S (2010). Recent developments and complexities in neutrophil transmigration.. nameOfConference

  
  

  DOI: 10.1097/MOH.0b013e3283333930

  
  

  QMRO: qmroHref
• Voisin M-B, Pröbstl D, Nourshargh S (2010). Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation.. nameOfConference

  
  

  DOI: 10.2353/ajpath.2010.090510

  
  

  QMRO: qmroHref
• Scheiermann C, Colom B, Meda P et al. (2009). Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury.. nameOfConference

  
  

  DOI: 10.1161/ATVBAHA.109.187559

  
  

  QMRO: qmroHref
• Voisin M-B, Woodfin A, Nourshargh S (2009). Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo.. nameOfConference

  
  

  DOI: 10.1161/ATVBAHA.109.187450

  
  

  QMRO: qmroHref
• Woodfin A, Voisin MB, Imhof BA et al. (2009). Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. nameOfConference

  
  

  DOI: 10.1182/blood-2008-11188375

  
  

  QMRO: qmroHref
• Woodfin A, Voisin M-B, Imhof BA et al. (2009). Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1.. nameOfConference

  
  

  DOI: 10.1182/blood-2008-11-188375

  
  

  QMRO: qmroHref
• Proebstl D, Voisin M-B, Nourshargh S (2009). Pericytes facilitate leukocyte transmigration in vivo. nameOfConference

  
  

  DOI: 10.1096/fasebj.23.1_supplement.360.1

  
  

  QMRO: qmroHref
• Woodfin A, Voisin M-B, Nourshargh S (2007). PECAM-1: a multi-functional molecule in inflammation and vascular biology.. nameOfConference

  
  

  DOI: 10.1161/ATVBAHA.107.151456

  
  

  QMRO: qmroHref
• Woodfin A, Reichel CA, Khandoga A et al. (2007). JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration.. nameOfConference

  
  

  DOI: 10.1182/blood-2006-09-047431

  
  

  QMRO: qmroHref
• Young RE, Voisin M-B, Wang S et al. (2007). Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice.. nameOfConference

  
  

  DOI: 10.1038/sj.bjp.0707267

  
  

  QMRO: qmroHref
• Voisin MB, Woodfin A, Nourshargh S (2007). Neutrophil and monocyte transmigration elicited by ischemia/reperfusion (I/R) injury and CCL2 is associated with remodelling of the venular basement membrane (BM) in vivo. nameOfConference

  
  

  DOI: 10.1096/fasebj.21.5.a127-a

  
  

  QMRO: qmroHref
• Wang S, Voisin M-B, Larbi KY et al. (2006). Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils.. nameOfConference

  
  

  DOI: 10.1084/jem.20051210

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18599
• Voisin MB, Woodfin A, Dawes T et al. (2006). Neutrophil elastase (NE) deficient mice exhibit reduced leukocyte transmigration in response to ischaemia/reperfusion (I/R) injury. nameOfConference

  
  

  DOI: 10.1096/fasebj.20.5.a1083-c

  
  

  QMRO: qmroHref
• Voisin MB, Wang SJ, Larbi K et al. (2006). Neutrophils play a direct role in enhancing the size of venular basement membrane (BM) matrix protein low expression regions. nameOfConference

  
  

  DOI: 10.1096/fasebj.20.5.a1322-b

  
  

  QMRO: qmroHref
• Voisin MB, Young R, Dangerfield J et al. (2005). LTB4 is a potent inducer of cell surface neutrophil elastase (NE), a response that appears to play a role in LTB4-induced neutrophil transmigration in vivo. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Wang SJ, Dangerfield J, Voisin MB et al. (2005). Pre-formed matrix protein "low expression" regions act as exit points for leukocytes migrating through the venular perivascular basement membrane. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Voisin M-B, Buzoni-Gatel D, Bout D et al. (2004). Both expansion of regulatory GR1+ CD11b+ myeloid cells and anergy of T lymphocytes participate in hyporesponsiveness of the lung-associated immune system during acute toxoplasmosis.. nameOfConference

  
  

  DOI: 10.1128/IAI.72.9.5487-5492.2004

  
  

  QMRO: qmroHref
• Voisin M-B, Bitard J, Daburon S et al. (2002). Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation.. nameOfConference

  
  

  DOI: 10.1074/jbc.M111624200

  
  

  QMRO: qmroHref

Collaborators

Internal

• Prof S. Nourshargh (WHRI)
• Prof C. Pitzalis (WHRI)
• Prof M. Perretti (WHRI)
• Dr P Longhi (WHRI)
• Prof A Nissim (WHRI)
• Prof F Marelli-Berg (WHRI)
• Dr M. Capasso (BCI)
• Dr Esther Castellano Sanchez (BCI)

External

• Prof Q. Sattentau (Oxford)
• Prof R Chambers (UCL)
• Prof J Greenwood (UCL)
• Prof J. Gutierrez (Costa Rica)
• Prof Ed Rainger (University of Birmingham)

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