Professor Michael Barnes

Profile

Michael co-leads the Centre for Translational Bioinformatics (C4TB), at Queen Mary University of London and is a Fellow of the Digitial Environment Research Institute, QMUL. His team work across diverse research areas, including genomics, drug discovery, stratified medicine, machine learning and health informatics with a unified objective to drive forward translation into the clinic. He brings an industrial perspective to the C4TB, drawn from 16 years of leadership of bioinformatics teams in the pharmaceutical industry.

Michael is a Fellow of the Alan Turing Institute and an HDR-UK Investigator, and co-leads the Genomics England Stratified medicine genomic interpretation clinical partnership. He has an active portfolio of stratified medicine projects as a co-investigator and data integration lead on several MRC projects, including MRC PSORT (Psoriasis), MRC RA-Map (RA), MRC MATURA (RA), and CLUSTER (Juvenile Arthritis). He also co-leads the NIHR AI-Multiply Consortium which is using AI to investigate the relationship between multiple long-term conditions and polypharmacy. He has served on the MRC Methodology Research Panel and Stratified Medicine panels and also advises on a number of project boards, including the UnitedHealth Group Pharmacogenetics advisory group, the Dutch Heart Foundation, the MRC-eMedLab HPC Cloud facility, the IMI etriks project, and the F1000 faculty. 

Research

Publications

• Leong IUS, Cabrera CP, Cipriani V et al. (2024). Large-Scale Pharmacogenomics Analysis of Patients With Cancer Within the 100,000 Genomes Project Combining Whole-Genome Sequencing and Medical Records to Inform Clinical Practice.. nameOfConference

  
  

  DOI: 10.1200/jco.23.02761

  
  

  QMRO: qmroHref
• Wenteler A, Cabrera CP, Wei W et al. (2024). AI approaches for the discovery and validation of drug targets. nameOfConference

  
  

  DOI: 10.1017/pcm.2024.4

  
  

  QMRO: qmroHref
• Henkin R, Goldmann K, Lewis M et al. (2024). shinyExprPortal: a configurable ‘shiny’ portal for sharing analysis of molecular expression data. nameOfConference

  
  

  DOI: 10.1093/bioinformatics/btae172

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/99464
• Calero-Díaz H, Hamad RA, Atallah C et al. (2023). Interpretable and robust hospital readmission predictions from Electronic Health Records. 2023 IEEE International Conference on Big Data (BigData)

  
  

  DOI: 10.1109/bigdata59044.2023.10386820

  
  

  QMRO: qmroHref
• Goldmann K, Spiliopoulou A, Iakovliev A et al. (2024). Expression quantitative trait loci analysis in rheumatoid arthritis identifies tissue specific variants associated with severity and outcome. nameOfConference

  
  

  DOI: 10.1136/ard-2023-224540

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91722
• Eto F, Samuel M, Henkin R et al. (publicationYear). Ethnic differences in early onset multimorbidity and associations with health service use, long-term prescribing, years of life lost, and mortality: A cross-sectional study using clustering in the UK Clinical Practice Research Datalink. nameOfConference

  
  

  DOI: 10.1371/journal.pmed.1004300

  
  

  QMRO: qmroHref
• Beesley R, Feilding FL, Beesley R et al. (2024). Development and implementation of ‘A guide to PPIE – Early Integration into Research Proposals’ in a multi-disciplinary consortium. nameOfConference

  
  

  DOI: 10.1093/rheumatology/kead482

  
  

  QMRO: qmroHref
• Ng S, Masarone S, Watson D et al. (2023). The benefits and pitfalls of machine learning for biomarker discovery. nameOfConference

  
  

  DOI: 10.1007/s00441-023-03816-z

  
  

  QMRO: qmroHref
• Lawson-Tovey S, Smith SL, Geifman N et al. (publicationYear). The successes and challenges of harmonising juvenile idiopathic arthritis (JIA) datasets to create a large-scale JIA data resource. nameOfConference

  
  

  DOI: 10.1186/s12969-023-00839-2

  
  

  QMRO: qmroHref
• Lewis MJ, Spiliopoulou A, Goldmann K et al. (2023). nestedcv: an R package for fast implementation of nested cross-validation with embedded feature selection designed for transcriptomics and high-dimensional data. nameOfConference

  
  

  DOI: 10.1093/bioadv/vbad048

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86188
• Voros S, Bansal AT, Barnes MR et al. (publicationYear). Bayesian network analysis of panomic biological big data identifies the importance of triglyceride-rich LDL in atherosclerosis development. nameOfConference

  
  

  DOI: 10.3389/fcvm.2022.960419

  
  

  QMRO: qmroHref
• Fernandes D, Khambata RS, Massimo G et al. (2023). Local delivery of nitric oxide prevents endothelial dysfunction in periodontitis. nameOfConference

  
  

  DOI: 10.1016/j.phrs.2022.106616

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86195
• Kremer R, Raza SM, Eto F et al. (2022). Tracking trajectories of multiple long-term conditions using dynamic patient-cluster associations. 2022 IEEE International Conference on Big Data (Big Data)

  
  

  DOI: 10.1109/bigdata55660.2022.10021034

  
  

  QMRO: qmroHref
• Boot J, Rosser G, Kancheva D et al. (publicationYear). Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape. nameOfConference

  
  

  DOI: 10.7554/elife.77335

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/83000
• Abdulkareem M, Kenawy AA, Rauseo E et al. (publicationYear). Predicting post-contrast information from contrast agent free cardiac MRI using machine learning: Challenges and methods. nameOfConference

  
  

  DOI: 10.3389/fcvm.2022.894503

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/83580
• Cooles FAH, Tarn J, Lendrem DW et al. (2022). Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2022-222370

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/85701
• Hunt GP, Grassi L, Henkin R et al. (2022). GEOexplorer: a webserver for gene expression analysis and visualisation. nameOfConference

  
  

  DOI: 10.1093/nar/gkac364

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79209
• Rivellese F, Surace AEA, Goldmann K et al. (2022). Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial. nameOfConference

  
  

  DOI: 10.1038/s41591-022-01789-0

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78741
• (publicationYear). RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients. nameOfConference

  
  

  DOI: 10.1038/s41597-022-01264-y

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/78946
• Tarn J, Lendrem D, Barnes M et al. (publicationYear). Comorbidities in the UK Primary Sjögren’s Syndrome Registry. nameOfConference

  
  

  DOI: 10.3389/fimmu.2022.864448

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79066
• Solanky S, Ejarque RA, Khan S et al. (2022). IL-23-induced STAT3 translocation in MAIT cells at baseline is a candidate biomarker of response for biologics targeting the IL-23/IL-17 axis. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79421
• Solanky S, Ejarque RA, Tosi I et al. (2022). Interleukin-23-induced STAT3 translocation in circulating mucosal-associated invariant T cells is a potential biomarker of clinical response to ustekinumab in psoriasis. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79322
• Hardman-Smart JA, Ejarque RA, Solanky S et al. (2022). Relative frequency of monocyte subsets at baseline in psoriasis is associated with clinical outcome to secukinumab therapy. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79321
• Saengkaew T, Ruiz-Babot G, David A et al. (publicationYear). Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty. nameOfConference

  
  

  DOI: 10.1038/s41525-021-00274-w

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/76132
• Andres-Ejarque R, Ale HB, Grys K et al. (publicationYear). Author Correction: Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis. nameOfConference

  
  

  DOI: 10.1038/s41467-021-27447-6

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79210
• Smedley D, Smith KR, Martin AR et al. (2021). 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report. nameOfConference

  
  

  DOI: 10.1056/nejmoa2035790

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79432
• Barnes M, Brockbank S, Bruce IN et al. (2021). Characterization of disease course and remission in early seropositive rheumatoid arthritis: results from the TACERA longitudinal cohort study. nameOfConference

  
  

  DOI: 10.1177/1759720x211043977

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79059
• Andres-Ejarque R, Ale HB, Grys K et al. (publicationYear). Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis. nameOfConference

  
  

  DOI: 10.1038/s41467-021-25066-9

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79423
• Geifman N, Azadbakht N, Zeng J et al. (2021). Defining trajectories of response in patients with psoriasis treated with biologic therapies. nameOfConference

  
  

  DOI: 10.1111/bjd.20140

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79070
• Saengkaew T, Mancini A, Ruiz-Babot G et al. (2021). Defects in the GnRH Neuronal Migration factor, CCDC141, Lead to Self-Limited Delayed Puberty. nameOfConference

  
  

  DOI: 10.1210/jendso/bvab048.1358

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71870
• Yiu ZZN, Barker JNWN, Barnes MR et al. (2021). Meeting Report: Psoriasis Stratification to Optimize Relevant Therapy Showcase. nameOfConference

  
  

  DOI: 10.1016/j.jid.2021.02.746

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79420
• Surendran P, Feofanova EV, Lahrouchi N et al. (2021). Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. nameOfConference

  
  

  DOI: 10.1038/s41588-021-00832-z

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79425
• Shoop-Worrall SJW, Hyrich KL, Wedderburn LR et al. (2021). Patient-reported wellbeing and clinical disease measures over time captured by multivariate trajectories of disease activity in individuals with juvenile idiopathic arthritis in the UK: a multicentre prospective longitudinal study. nameOfConference

  
  

  DOI: 10.1016/s2665-9913(20)30269-1

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79061
• Surendran P, Feofanova EV, Lahrouchi N et al. (2020). Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. nameOfConference

  
  

  DOI: 10.1038/s41588-020-00713-x

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/69571
• Aarum J, Cabrera CP, Jones TA et al. (2020). Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates. nameOfConference

  
  

  DOI: 10.15252/embr.201949585

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68516
• Aarum J, Cabrera CP, Jones TA et al. (2020). Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates. nameOfConference

  
  

  DOI: 10.15252/embr.201949585

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/69500
• Cherlin S, Lewis MJ, Plant D et al. (2020). Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between IL18RAP expression and treatment response. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2020-217204

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66355
• Mancini A, Howard SR, Marelli F et al. (2020). LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling. nameOfConference

  
  

  DOI: 10.1172/jci.insight.133434

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65142
• Ntalla I, Weng L-C, Cartwright JH et al. (publicationYear). Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. nameOfConference

  
  

  DOI: 10.1038/s41467-020-15706-x

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66431
• Nicholls HL, John CR, Watson DS et al. (publicationYear). Reaching the End-Game for GWAS: Machine Learning Approaches for the Prioritization of Complex Disease Loci. nameOfConference

  
  

  DOI: 10.3389/fgene.2020.00350

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64760
• Loeff FC, Tsakok T, Dijk L et al. (2020). Clinical Impact of Antibodies against Ustekinumab in Psoriasis: An Observational, Cross-Sectional, Multicenter Study. nameOfConference

  
  

  DOI: 10.1016/j.jid.2020.03.957

  
  

  QMRO: qmroHref
• Hemingway H, Lyons R, Li Q et al. (2020). A national initiative in data science for health: an evaluation of the UK Farr Institute.. nameOfConference

  
  

  DOI: 10.23889/ijpds.v5i1.1128

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/76257
• John CR, Watson D, Russ D et al. (2020). M3C: Monte Carlo reference-based consensus clustering. nameOfConference

  
  

  DOI: 10.1038/s41598-020-58766-1

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/63004
• Pan S, Tsakok T, Dand N et al. (2020). Using Real‐World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic‐Pharmacodynamic Study. nameOfConference

  
  

  DOI: 10.1111/cts.12725

  
  

  QMRO: qmroHref
• Ricci B, Millner TO, Pomella N et al. (2020). Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma. nameOfConference

  
  

  DOI: 10.1038/s41388-020-1161-3

  
  

  QMRO: qmroHref
• Cabrera CP, Pazoki R, Giri A et al. (2020). Multi-trait genome-wide association analysis of blood pressure identifies 45 additional loci. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71792
• Smit RAJ, Trompet S, Leong A et al. (2019). Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study. nameOfConference

  
  

  DOI: 10.1038/s41397-019-0125-x

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/62179
• Tsakok T, Wilson N, Dand N et al. (2019). Association of Serum Ustekinumab Levels With Clinical Response in Psoriasis. nameOfConference

  
  

  DOI: 10.1001/jamadermatol.2019.1783

  
  

  QMRO: qmroHref
• Mancini A, Howard SR, Cabrera CP et al. (publicationYear). Defects in LGR4 Wnt-[beta]-catenin signalling impair GnRH network development, leading to delayed puberty. nameOfConference

  
  

  DOI: 10.1530/endoabs.66.oc4.3

  
  

  QMRO: qmroHref
• Petersen S, Munroe P, Aung N et al. (publicationYear). Genome-wide analysis of left ventricular image-derived phenotypes identifies fourteen loci associated with cardiac morphogenesis and heart failure development. nameOfConference

  
  

  DOI: 10.1161/CIRCULATIONAHA.119.041161

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/59778
• John CR, Watson D, Barnes MR et al. (2020). Spectrum: fast density-aware spectral clustering for single and multi-omic data. nameOfConference

  
  

  DOI: 10.1093/bioinformatics/btz704

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64588
• Caley M, Marsh S, Martins VL et al. (2019). 298 Defective DNA Repair and Chromosomal Instability in RDEB. nameOfConference

  
  

  DOI: 10.1016/j.jid.2019.07.299

  
  

  QMRO: qmroHref
• Lewis MJ, Barnes MR, Blighe K et al. (2019). Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes. nameOfConference

  
  

  DOI: 10.1016/j.celrep.2019.07.091

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/59563
• Cabrera CP, Ng F, Nicholls HL et al. (2019). Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated.. nameOfConference

  
  

  DOI: 10.1093/hmg/ddz197

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/61878
• Thomas AM, Cabrera CP, Finlay M et al. (2019). Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages.. nameOfConference

  
  

  DOI: 10.1152/physiolgenomics.00012.2019

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/59231
• Aung N, Vargas JD, Manichaikul AW et al. (2019). 199Genetic architecture of left ventricular phenotypes derived from 17,000 CMR studies in the UK Biobank population imaging cohort. nameOfConference

  
  

  DOI: 10.1093/ehjci/jez128

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66436
• Aung N, Vargas JD, Manichaikul AW et al. (2019). P463Heritability and genotypic correlation of CMR-derived LV phenotypes in the UK Biobank population imaging study. nameOfConference

  
  

  DOI: 10.1093/ehjci/jez118.046

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66851
• John CR, Watson D, Barnes M et al. (publicationYear). Spectrum: Fast density-aware spectral clustering for single and multi-omic data. nameOfConference

  
  

  DOI: 10.1101/636639

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65942
• Howard S, Cabrera C, Barnes M et al. (2019). MON-LB048 Delayed or Absent? Use of Next Generation Sequencing Diagnostic Tools in a UK Puberty Cohort. nameOfConference

  
  

  DOI: 10.1210/js.2019-mon-lb048

  
  

  QMRO: qmroHref
• HUMBY F (2019). Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2018-214539

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/58941
• Watson DS, Krutzinna J, Bruce IN et al. (publicationYear). Clinical applications of machine learning algorithms: beyond the black box. nameOfConference

  
  

  DOI: 10.1136/bmj.l886

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/58843
• Bodagh N, Archbold RA, Weerackody R et al. (2018). Feasibility of real-time capture of routine clinical data in the electronic health record: a hospital-based, observational service-evaluation study.. nameOfConference

  
  

  DOI: 10.1136/bmjopen-2017-019790

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/54835
• Mancini A, Howard SR, Cabrera CP et al. (2019). EAP1 regulation of GnRH promoter activity is important for human pubertal timing. nameOfConference

  
  

  DOI: 10.1093/hmg/ddy451

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/55065
• Foulkes AC, Watson DS, Carr DF et al. (2019). A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis.. nameOfConference

  
  

  DOI: 10.1016/j.jid.2018.04.041

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/54949
• Aung N, Vargas JD, Manichaikul AW et al. (2019). Genetic architecture of left ventricular phenotypes derived from 17,000 CMR studies in the UK Biobank population imaging cohort. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65659
• Aung N, Vargas JD, Manichaikul AW et al. (2019). Heritability and genotypic correlation of CMR-derived LV phenotypes in the UK Biobank population imaging study. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65687
• Mancini A, Howard SR, Cabrera CP et al. (2019). LGR 4-Wnt β-catenin signalling directs GnRH network development, with defects leading to self-limited delayed puberty. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/69227
• CHAPPLE JP, O'TOOLE S, WATSON D et al. (2019). Oncometabolite induced primary cilia loss in pheochromocytoma. nameOfConference

  
  

  DOI: 10.1530/ERC-18-0134

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/44923
• Dand N, Duckworth M, Baudry D et al. (2019). HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis. nameOfConference

  
  

  DOI: 10.1016/j.jaci.2018.11.038

  
  

  QMRO: qmroHref
• Cope AP, Barnes MR, Belson A et al. (2018). The RA-MAP Consortium: a working model for academia-industry collaboration.. nameOfConference

  
  

  DOI: 10.1038/nrrheum.2017.200

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/35063
• Evangelou E, Warren HR, Mosen-Ansorena D et al. (2018). Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.. nameOfConference

  
  

  DOI: 10.1038/s41588-018-0297-3

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/56068
• Cabrera CP, Manson J, Shepherd JM et al. (2018). Correction: Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.. nameOfConference

  
  

  DOI: 10.1371/journal.pmed.1002694

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/58929
• Consortium R-M (2018). Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data. nameOfConference

  
  

  DOI: 10.1136/rmdopen-2018-000721

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/63758
• Costa ARD, Qarin S, Bradshaw T et al. (publicationYear). Can novel stem cell models help unpick the pathogenesis of the Triple A syndrome?. nameOfConference

  
  

  DOI: 10.1530/endoabs.58.oc5.3

  
  

  QMRO: qmroHref
• Howard SR, Cabrera CP, Barnes MR et al. (publicationYear). Delayed or Absent? - use of next generation sequencing diagnostic tools in a UK puberty cohort. nameOfConference

  
  

  DOI: 10.1530/endoabs.58.oc4.5

  
  

  QMRO: qmroHref
• Cherlin S, Plant D, Taylor JC et al. (2018). Prediction of treatment response in rheumatoid arthritis patients using genome‐wide SNP data. nameOfConference

  
  

  DOI: 10.1002/gepi.22159

  
  

  QMRO: qmroHref
• Evangelou E, Warren HR, Mosen-Ansorena D et al. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. nameOfConference

  
  

  DOI: 10.1038/s41588-018-0205-x

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/47343
• Da Costa AR, Qarin S, Bradshaw TY et al. (2018). A Novel Stem Cell Model for the Triple a Syndrome. 57th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE)

  
  

  DOI: 10.1159/000492307

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64999
• Tragante V, Hemerich D, Alshabeeb M et al. (2018). Druggability of Coronary Artery Disease Risk Loci.. nameOfConference

  
  

  DOI: 10.1161/CIRCGEN.117.001977

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/59036
• Jones TF, Torrance HDT, Owen HC et al. (2018). MicroRNA profiles are associated with lymphocyte count after a major traumatic injury: a potential role for immunometabolism?. nameOfConference

  
  

  DOI: 10.1016/j.bja.2018.05.027

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/45685
• John C, Watson D, Russ D et al. (2018). M3C: Monte Carlo reference-based consensus clustering. nameOfConference

  
  

  DOI: 10.1101/377002

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64683
• Kapil V, Rathod KS, Khambata RS et al. (2018). Sex differences in the nitrate-nitrite-NO• pathway: Role of oral nitrate-reducing bacteria. nameOfConference

  
  

  DOI: 10.1016/j.freeradbiomed.2018.07.010

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/55110
• Lewis MJ, Barnes MR (2018). RNA sequencing and machine learning as molecular scalpels.. nameOfConference

  
  

  DOI: 10.1038/s41584-018-0012-x

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/39553
• Howard SR, Oleari R, Poliandri A et al. (2018). HS6ST1 Insufficiency Causes Self-Limited Delayed Puberty in Contrast With Other GnRH Deficiency Genes. nameOfConference

  
  

  DOI: 10.1210/jc.2018-00646

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/42223
• Warren HR, Evangelou E, Mosen D et al. (2018). GENETIC ANALYSIS OF OVER ONE MILLION PEOPLE IDENTIFIES 535 NOVEL LOCI ASSOCIATED WITH BLOOD PRESSURE AND RISK OF CARDIOVASCULAR DISEASE. nameOfConference

  
  

  DOI: 10.1097/01.hjh.0000539644.13726.3b

  
  

  QMRO: qmroHref
• Taylor JC, Bongartz T, Massey J et al. (2018). Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients. nameOfConference

  
  

  DOI: 10.1038/s41397-018-0025-5

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/54860
• Marsh S, Caley MP, Martins V et al. (2018). 812 Type VII collagen and Nesprin 2, LINCing the basement membrane to altered cell cycle and increased DNA damage. nameOfConference

  
  

  DOI: 10.1016/j.jid.2018.03.822

  
  

  QMRO: qmroHref
• Foulkes AC, Watson DS, Barnes MR (2018). Bioinformatics for dermatology: why we should learn about code.. nameOfConference

  
  

  DOI: 10.1111/bjd.16277

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/59053
• Cope AP, Barnes MR, Belson A et al. (2018). Erratum: The RA-MAP Consortium: a working model for academia–industry collaboration. nameOfConference

  
  

  DOI: 10.1038/nrrheum.2018.6

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65530
• Mancini A, Howard SR, Cabrera CP et al. (2018). EAP1 Mutations Cause an Impaired Transcriptional Activity on GnRH Promoter That Leads to Self-Limited Delayed Puberty. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/69230
• Thorneloe RJ, Griffiths CEM, Emsley R et al. (2018). Intentional and Unintentional Medication Non-Adherence in Psoriasis: The Role of Patients’ Medication Beliefs and Habit Strength. nameOfConference

  
  

  DOI: 10.1016/j.jid.2017.11.015

  
  

  QMRO: qmroHref
• Howard SR, Guasti L, Poliandri A et al. (2018). Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty. nameOfConference

  
  

  DOI: 10.1210/jc.2017-02147

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/32184
• Howard S, Andre V, Guasti L et al. (publicationYear). Patients with self-limited delayed puberty harbour mutations in multiple genes controlling GnRH neuronal development. nameOfConference

  
  

  DOI: 10.1530/endoabs.51.oc4.1

  
  

  QMRO: qmroHref
• Marsh S, Caley M, Martins V et al. (2017). Loss of keratinocyte type VII collagen induces increased DNA damage in vitro and in vivo. ESDR 2017

  
  

  DOI: 10.1016/j.jid.2017.07.189

  
  

  QMRO: qmroHref
• Kraja AT, Cook JP, Warren HR et al. (2017). New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals. nameOfConference

  
  

  DOI: 10.1161/circgenetics.117.001778

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/56729
• Warren HR, Evangelou E, Cabrera CP et al. (2017). Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.. nameOfConference

  
  

  DOI: 10.1038/ng1017-1558a

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/50805
• Foulkes AC, Watson DS, Griffiths CEM et al. (2017). Research Techniques Made Simple: Bioinformatics for Genome-Scale Biology. nameOfConference

  
  

  DOI: 10.1016/j.jid.2017.07.095

  
  

  QMRO: qmroHref
• Wain LV, Vaez A, Jansen R et al. (2017). Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. nameOfConference

  
  

  DOI: 10.1161/hypertensionaha.117.09438

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/26603
• MARINO S, Dibenedetto S, Niklison-Chirou M et al. (2017). Enhanced energetic state and protection from oxidative stress in human myoblasts overexpressing BMI1.. nameOfConference

  
  

  DOI: 10.1016/j.stemcr.2017.06.009

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/24887
• CABRERA CP, MANSON J, SHEPHERD JM et al. (2017). Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma. nameOfConference

  
  

  DOI: 10.1371/journal.pmed.1002352

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/26246
• Sordi R, Nandra KK, Chiazza F et al. (2017). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation.. nameOfConference

  
  

  DOI: 10.1097/SLA.0000000000001664

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19199
• Cabrera CP, Manson J, Shepherd JM et al. (2017). Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.. nameOfConference

  
  

  DOI: 10.1371/journal.pmed.1002352

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/25043
• Bodagh N, Archbold A, Weerackody R et al. (2017). 100 Powerform for real-time entry of routine cardiac outpatient data into the electronic health record: application for audit and research. nameOfConference

  
  

  DOI: 10.1136/heartjnl-2017-311726.99

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/37884
• Warren HR, Evangelou E, Cabrera CP et al. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.. nameOfConference

  
  

  DOI: 10.1038/ng.3768

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19169
• Howard SR, Andre V, Guasti L et al. (2017). DISCOVERY OF MUTATIONS IN MULTIPLE GENES CONTROLLING GNRH NEURONAL MIGRATION AND DEVELOPMENT IN PATIENTS WITH SELF-LIMITED DELAYED PUBERTY. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/69233
• Gagliano SA, Pouget JG, Hardy J et al. (2016). Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases. nameOfConference

  
  

  DOI: 10.1002/acn3.369

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/22711
• Mancini A, Howard SR, Ruiz-Babot G et al. (publicationYear). LGR4 and EAP1 mutations are implicated in the phenotype of self-limited delayed puberty. nameOfConference

  
  

  DOI: 10.1530/endoabs.44.p139

  
  

  QMRO: qmroHref
• Hosking A, Koulouroudias M, Zemrak F et al. (2016). Evaluation of splenic switch off in a tertiary imaging centre: validation and assessment of utility. nameOfConference

  
  

  DOI: 10.1093/ehjci/jew205

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/16222
• Shaked A, Chang B, Barnes MR et al. (2017). An ectopically expressed serum miRNA signature is prognostic, diagnostic, and biologically related to liver allograft rejection. nameOfConference

  
  

  DOI: 10.1002/hep.28786

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/56195
• Smit RA, Postmus I, Trompet S et al. (2016). Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment.. nameOfConference

  
  

  DOI: 10.2217/pgs-2016-0091

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/16224
• MUNROE PB (publicationYear). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. nameOfConference

  
  

  DOI: 10.1038/ng.3667

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/15563
• Foulkes AC, Watson DS, Rattray NJ et al. (2016). 039 Systems biology approach to the analysis of pharmacogenomic data in psoriasis. nameOfConference

  
  

  DOI: 10.1016/j.jid.2016.06.056

  
  

  QMRO: qmroHref
• Postmus I, Warren HR, Trompet S et al. (2016). Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.. nameOfConference

  
  

  DOI: 10.1136/jmedgenet-2016-103966

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15127
• Broad J, Maurel D, Kung VWS et al. (publicationYear). Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design. nameOfConference

  
  

  DOI: 10.1038/srep30797

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15914
• Jia Z, Liu Y, Guan N et al. (2016). Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied to drug repositioning and drug mode of action discovery. nameOfConference

  
  

  DOI: 10.1186/s12864-016-2737-8

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/22628
• Narasimhan VM, Hunt KA, Mason D et al. (2016). Health and population effects of rare gene knockouts in adult humans with related parents.. nameOfConference

  
  

  DOI: 10.1126/science.aac8624

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/11646
• HOWARD SR, Guasti L, Ruiz-Babot G et al. (2016). IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty. nameOfConference

  
  

  DOI: 10.15252/emmm.201606250

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18622
• Tragante V, Braenne I, Moore JH et al. (2016). Evaluating CAD/MI loci as targets for prevention of myocardial infarction. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Reglero N, Beal R, Cabrera C et al. (2016). JAM‐C deficiency primes endothelial cells for a pro‐inflammatory state. nameOfConference

  
  

  DOI: 10.1096/fasebj.30.1_supplement.165.10

  
  

  QMRO: qmroHref
• Howard S, Guasti L, Ruiz-Babot G et al. (2016). Role of IGSF10 mutations in self-limited delayed puberty. nameOfConference

  
  

  DOI: 10.1016/s0140-6736(16)00401-3

  
  

  QMRO: qmroHref
• Gagliano SA, Pouget JG, Hardy J et al. (2016). Genetic Variability in Both the Adaptive and Innate Immune Systems Contribute to Alzheimer's and Parkinson's Disease Risk. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/54830
• Griffiths CEM, Barnes MR, Burden AD et al. (2015). Establishing an Academic–Industrial Stratified Medicine Consortium: Psoriasis Stratification to Optimize Relevant Therapy. nameOfConference

  
  

  DOI: 10.1038/jid.2015.286

  
  

  QMRO: qmroHref
• Howard S, Poliandre A, Storr HL et al. (publicationYear). Mutations in HS6ST1 cause self-limited delayed puberty (DP) in addition to idiopathic hypogonadotropic hypogonadism (IHH). nameOfConference

  
  

  DOI: 10.1530/endoabs.39.p1

  
  

  QMRO: qmroHref
• Howard S, Guasti L, Ruiz-Babot G et al. (publicationYear). Mutations in IGSF10 cause self-limited delayed puberty. nameOfConference

  
  

  DOI: 10.1530/endoabs.39.oc5.1

  
  

  QMRO: qmroHref
• Kokkinopoulos I, Ishida H, Saba R et al. (publicationYear). Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo. nameOfConference

  
  

  DOI: 10.1371/journal.pone.0140831

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/13417
• Howard S, Poliandri A, Storr H et al. (publicationYear). Mutations in HS6ST1 are causal in self-limited delayed puberty as well as idiopathic hypogonadotropic hypogonadism. nameOfConference

  
  

  DOI: 10.1530/endoabs.38.oc6.3

  
  

  QMRO: qmroHref
• Howard S, Guasti L, Ruiz-Babot G et al. (publicationYear). Mutations in IGSF10 cause self-limited delayed puberty, via disturbance of GnRH neuronal migration. nameOfConference

  
  

  DOI: 10.1530/endoabs.38.oc1.2

  
  

  QMRO: qmroHref
• Owen H, Torrance H, Barnes M et al. (2015). The Role of Micrornas in The Development of Hospital Acquired Infection in Polytrauma Patients. nameOfConference

  
  

  DOI: 10.1186/2197-425x-3-s1-a35

  
  

  QMRO: qmroHref
• Jia Z, Zhang X, Guan N et al. (publicationYear). Gene Ranking of RNA-Seq Data via Discriminant Non-Negative Matrix Factorization. nameOfConference

  
  

  DOI: 10.1371/journal.pone.0137782

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/23531
• Gagliano SA, Ravji R, Barnes MR et al. (publicationYear). Smoking Gun or Circumstantial Evidence? Comparison of Statistical Learning Methods using Functional Annotations for Prioritizing Risk Variants. nameOfConference

  
  

  DOI: 10.1038/srep13373

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/24747
• Lanktree MB, Elbers CC, Li Y et al. (2015). Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration[S]. nameOfConference

  
  

  DOI: 10.1194/jlr.p059477

  
  

  QMRO: qmroHref
• Carlotti E, Floyd J, Murray-Brown W et al. (2015). FRI0008 Longitudinal Analysis of the IGH-VH Gene by High-Throughput Sequencing in Early Rheumatoid Arthritis Paired Biopsies and its Association with Response to Dmards. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2015-eular.5499

  
  

  QMRO: qmroHref
• Taylor PN, Porcu E, Chew S et al. (publicationYear). Erratum: Whole-genome sequence-based analysis of thyroid function. nameOfConference

  
  

  DOI: 10.1038/ncomms8172

  
  

  QMRO: qmroHref
• Rodriguez S, Gaunt TR, Guo Y et al. (2016). Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array. nameOfConference

  
  

  DOI: 10.1038/ejhg.2015.63

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/23506
• Peyrot WJ, Lee SH, Milaneschi Y et al. (2015). The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects. nameOfConference

  
  

  DOI: 10.1038/mp.2015.50

  
  

  QMRO: qmroHref
• Taylor PN, Porcu E, Chew S et al. (publicationYear). Whole-genome sequence-based analysis of thyroid function. nameOfConference

  
  

  DOI: 10.1038/ncomms6681

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/28888
• Rucker JJH, Tansey KE, Rivera M et al. (2016). Phenotypic Association Analyses With Copy Number Variation in Recurrent Depressive Disorder. nameOfConference

  
  

  DOI: 10.1016/j.biopsych.2015.02.025

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15103
• Cabrera CP, Ng FL, Warren HR et al. (2015). Exploring hypertension genome‐wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics. nameOfConference

  
  

  DOI: 10.1002/wsbm.1290

  
  

  QMRO: qmroHref
• O'Dushlaine C, Rossin L, Lee PH et al. (2015). Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. nameOfConference

  
  

  DOI: 10.1038/nn.3922

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/7547
• Maier R, Moser G, Chen G-B et al. (2015). Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder. nameOfConference

  
  

  DOI: 10.1016/j.ajhg.2014.12.006

  
  

  QMRO: qmroHref
• Gagliano SA, Ravji R, Barnes MR et al. (2015). A Methods Comparison: In silico prioritization of genetic risk variants using functional genomic information. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Postmus I, Trompet S, Deshmukh HA et al. (2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.. nameOfConference

  
  

  DOI: 10.1038/ncomms6068

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6802
• Marino S, Ceric D, Ricci B et al. (2014). O4.07A NOVEL POLYCOMB FEED FORWARD LOOP IN GLIOBLASTOMA MULTIFORME. nameOfConference

  
  

  DOI: 10.1093/neuonc/nou174.28

  
  

  QMRO: qmroHref
• Voros S, Maurovich-Horvat P, Marvasty IB et al. (2014). Precision phenotyping, panomics, and system-level bioinformatics to delineate complex biologies of atherosclerosis: Rationale and design of the “Genetic Loci and the Burden of Atherosclerotic Lesions” study. nameOfConference

  
  

  DOI: 10.1016/j.jcct.2014.08.006

  
  

  QMRO: qmroHref
• Marino S, Ricci B, Greco A et al. (2014). A NOVEL POLYCOMB FEED FORWARD LOOP IN GLIOBLASTOMA MULTIFORME. nameOfConference

  
  

  DOI: 10.1093/neuonc/nou206.64

  
  

  QMRO: qmroHref
• Gagliano SA, Barnes MR, Weale ME et al. (2014). A Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization. nameOfConference

  
  

  DOI: 10.1371/journal.pone.0098122

  
  

  QMRO: qmroHref
• Tragante V, Barnes MR, Ganesh SK et al. (2014). Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.. nameOfConference

  
  

  DOI: 10.1016/j.ajhg.2013.12.016

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/7839
• Howard S, Guasti L, Storr H et al. (publicationYear). A novel gene affecting the timing of puberty. nameOfConference

  
  

  DOI: 10.1530/endoabs.34.p158

  
  

  QMRO: qmroHref
• Ricci B, Ceric D, Barnes M et al. (2014). A NOVEL POLYCOMB FEED FORWARD LOOP IN GLIOBLASTOMA MULTIFORME. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Yoneyama S, Guo Y, Lanktree MB et al. (2014). Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. nameOfConference

  
  

  DOI: 10.1093/hmg/ddt626

  
  

  QMRO: qmroHref
• Marsh S, Martins V, Caley M et al. (2014). Global transcriptomic changes in primary keratinocytes with loss of basement membrane genes. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Foulkes AC, Rattray NJW, Correa E et al. (2014). Modulation of metabolomic signature on biological treatment with etanercept in psoriasis. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Trompet S, Postmus I, Deshmukh HA et al. (2014). Pharmacogenetic GWAS meta-analysis of LDL cholesterol response to statins. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6689
• Foulkes AC, Carr DF, Al-Sharqi A et al. (2014). Pharmacogenomic signatures of response to etanercept therapy for psoriasis. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Marsh S, Martins V, Caley M et al. (2014). RNA-Seqing the skin basement membrane. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S et al. (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.. nameOfConference

  
  

  DOI: 10.1038/ng.2711

  
  

  QMRO: qmroHref
• Munroe PB, Barnes MR, Caulfield MJ (2013). Advances in blood pressure genomics.. nameOfConference

  
  

  DOI: 10.1161/CIRCRESAHA.112.300387

  
  

  QMRO: qmroHref
• Howard S, Barnes M, Storr H et al. (2013). Familial constitutional delay in growth and puberty is a condition with significant genetic heterogeneity and limited overlap with the timing of puberty in the general population. nameOfConference

  
  

  DOI: 10.1530/endoabs.31.p145

  
  

  QMRO: qmroHref
• Sullivan PF, Daly MJ, Ripke S et al. (2013). A mega-analysis of genome-wide association studies for major depressive disorder. nameOfConference

  
  

  DOI: 10.1038/mp.2012.21

  
  

  QMRO: qmroHref
• Rucker JJH, Breen G, Pinto D et al. (2013). Genome-wide association analysis of copy number variation in recurrent depressive disorder. nameOfConference

  
  

  DOI: 10.1038/mp.2011.144

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18224
• Sanseau P, Agarwal P, Barnes MR et al. (2013). Rational drug repositioning by medical genetics Reply. nameOfConference

  
  

  DOI: 10.1038/nbt.2769

  
  

  QMRO: qmroHref
• Best LG, Saxena R, Anderson CM et al. (2013). Two Variants of the C-Reactive Protein Gene Are Associated with Risk of Pre-Eclampsia in an American Indian Population. nameOfConference

  
  

  DOI: 10.1371/journal.pone.0071231

  
  

  QMRO: qmroHref
• (2012). A COMT gene haplotype associated with methamphetamine abuse. nameOfConference

  
  

  DOI: 10.1097/fpc.0b013e328355e322

  
  

  QMRO: qmroHref
• Barnes MR (2012). An Open Innovation Ecosystem for Drug Discovery. nameOfConference

  
  

  DOI: 10.1039/c1md90048j

  
  

  QMRO: qmroHref
• Pedroso I, Lourdusamy A, Rietschel M et al. (2012). Common Genetic Variants and Gene-Expression Changes Associated with Bipolar Disorder Are Over-Represented in Brain Signaling Pathway Genes. nameOfConference

  
  

  DOI: 10.1016/j.biopsych.2011.12.031

  
  

  QMRO: qmroHref
• Sanseau P, Agarwal P, Barnes MR et al. (2012). Use of genome-wide association studies for drug repositioning. nameOfConference

  
  

  DOI: 10.1038/nbt.2151

  
  

  QMRO: qmroHref
• Knight J, Barnes MR, Breen G et al. (2011). Using functional annotation for the Empirical determination of Bayes factors for genome-wide association study analysis. nameOfConference

  
  

  DOI: 10.1371/journal.pone.0014808

  
  

  QMRO: qmroHref
• Dow DJ, Huxley-Jones J, Hall JM et al. (2011). ADAMTSL3 as a candidate gene for schizophrenia: Gene sequencing and ultra-high density association analysis by imputation. nameOfConference

  
  

  DOI: 10.1016/j.schres.2010.12.009

  
  

  QMRO: qmroHref
• Jugurnauth SK, Chen CK, Barnes MR et al. (2011). A COMT gene haplotype associated with methamphetamine abuse. nameOfConference

  
  

  DOI: 10.1097/FPC.0b013e32834a53f9

  
  

  QMRO: qmroHref
• Xu C-F, Reck BH, Goodman VL et al. (2011). Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma. nameOfConference

  
  

  DOI: 10.1016/j.jhep.2010.09.028

  
  

  QMRO: qmroHref
• Barnes MR, Huxley-Jones J, Maycox PR et al. (2011). Transcription and Pathway Analysis of the Superior Temporal Cortex and Anterior Prefrontal Cortex in Schizophrenia. nameOfConference

  
  

  DOI: 10.1002/jnr.22647

  
  

  QMRO: qmroHref
• Barnes M, Rompe JD, Furia J et al. (2010). Letter to the Editor. nameOfConference

  
  

  DOI: 10.1177/0363546510379345

  
  

  QMRO: qmroHref
• Lewis CM, Ng MY, Butler AW et al. (2010). Genome-Wide Association Study of Major Recurrent Depression in the UK Population. nameOfConference

  
  

  DOI: 10.1176/appi.ajp.2010.09091380

  
  

  QMRO: qmroHref
• Maycox PR, Kelly F, Taylor A et al. (2010). Erratum: Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. nameOfConference

  
  

  DOI: 10.1038/mp.2009.148

  
  

  QMRO: qmroHref
• Barnes MR, Breen G (2010). A short primer on the functional analysis of copy number variation for biomedical scientists.. nameOfConference

  
  

  DOI: 10.1007/978-1-60327-367-1_7

  
  

  QMRO: qmroHref
• Barnes MR (2010). Exploring the landscape of the genome.. nameOfConference

  
  

  DOI: 10.1007/978-1-60327-367-1_2

  
  

  QMRO: qmroHref
• Barnes MR (2010). Genetic variation analysis for biomedical researchers: a primer.. nameOfConference

  
  

  DOI: 10.1007/978-1-60327-367-1_1

  
  

  QMRO: qmroHref
• Uher R, Perroud N, Ng MYM et al. (2010). Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project. nameOfConference

  
  

  DOI: 10.1176/appi.ajp.2009.09070932

  
  

  QMRO: qmroHref
• Barnes MR, Breen G (2010). Preface: "Your genome is an email attachment". nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Maycox PR, Kelly F, Taylor A et al. (2009). Erratum: Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. nameOfConference

  
  

  DOI: 10.1038/mp.2009.32

  
  

  QMRO: qmroHref
• Barnes MR, Harland L, Foord SM et al. (2009). Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery.. nameOfConference

  
  

  DOI: 10.1038/nrd2944

  
  

  QMRO: qmroHref
• Maycox PR, Kelly F, Taylor A et al. (2009). Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. nameOfConference

  
  

  DOI: 10.1038/mp.2009.18

  
  

  QMRO: qmroHref
• Rujescu D, Ingason A, Cichon S et al. (2009). Disruption of the neurexin 1 gene is associated with schizophrenia. nameOfConference

  
  

  DOI: 10.1093/hmg/ddn351

  
  

  QMRO: qmroHref
• Huxley-Jones J, Foord SM, Barnes MR (2009). Drug discovery in the extracellular matrix. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Knight J, Barnes MR, Breen G et al. (2009). Functional annotation of GWAS hits. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Baranzini SE, Galwey NW, Wang J et al. (2009). Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. nameOfConference

  
  

  DOI: 10.1093/hmg/ddp120

  
  

  QMRO: qmroHref
• Huxley-Jones J, Foord SM, Barnes MR (2008). Drug discovery in the extracellular matrix.. nameOfConference

  
  

  DOI: 10.1016/j.drudis.2008.05.005

  
  

  QMRO: qmroHref
• Li H, Wetten S, Li L et al. (2008). Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.. nameOfConference

  
  

  DOI: 10.1001/archneurol.2007.3

  
  

  QMRO: qmroHref
• Bansal AT, Barnes MR (2008). Genomics in drug discovery: The best things come to those who wait. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Pettersson F, Morris AP, Barnes MR et al. (2008). Goldsurfer2 (Gs2): A comprehensive tool for the analysis and visualization of genome wide association studies. nameOfConference

  
  

  DOI: 10.1186/1471-2105-9-138

  
  

  QMRO: qmroHref
• Zhu G, Carlsen K, Carlsen K-H et al. (2008). Polymorphisms in the endothelin-1 (EDN1) are associated with asthma in two populations. nameOfConference

  
  

  DOI: 10.1038/sj.gene.6364441

  
  

  QMRO: qmroHref
• Chondrogiannis S, Barnes M, Osborne M et al. (2007). Point of Connection Voltage Regulation Strategies for AC Connected Large Offshore Wind Farms. nameOfConference

  
  

  DOI: 10.1260/030952407784079771

  
  

  QMRO: qmroHref
• Southan C, Ulvsbäck M, Barnes MR (2007). A Bioinformatics Perspective on Genetics in Drug Discovery and Development. nameOfConference

  
  

  DOI: 10.1002/9780470059180.ch19

  
  

  QMRO: qmroHref
• Barnes MR (2007). Bioinformatics Challenges for the Geneticist. nameOfConference

  
  

  DOI: 10.1002/9780470059180.ch1

  
  

  QMRO: qmroHref
• Barnes MR (2007). Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data: Second Edition. nameOfConference

  
  

  DOI: 10.1002/9780470059180

  
  

  QMRO: qmroHref
• Southan C, Barnes MR (2007). Finding, Delineating and Analysing Genes. nameOfConference

  
  

  DOI: 10.1002/9780470059180.ch5

  
  

  QMRO: qmroHref
• Barnes MR (2007). Integrating Genetics, Genomics and Epigenomics to Identify Disease Genes. nameOfConference

  
  

  DOI: 10.1002/9780470059180.ch9

  
  

  QMRO: qmroHref
• Barnes MR, Derwent PS (2007). Needle in a Haystack? Dealing with 500 000 SNP Genome Scans. nameOfConference

  
  

  DOI: 10.1002/9780470059180.ch18

  
  

  QMRO: qmroHref
• Brown JR, Deharo S, Dancis B et al. (2007). Non-Coding RNA Bioinformatics. nameOfConference

  
  

  DOI: 10.1002/9780470059180.ch14

  
  

  QMRO: qmroHref
• Plumpton M, Barnes MR (2007). Predictive Functional Analysis of Polymorphisms: An Overview. nameOfConference

  
  

  DOI: 10.1002/9780470059180.ch11

  
  

  QMRO: qmroHref
• Barnes MR (2007). Preface. nameOfConference

  
  

  DOI: 10.1002/9780470059180

  
  

  QMRO: qmroHref
• Barnes MR (2007). Bioinformatics for Geneticists. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Teh MT, Blaydon D, Ghali LR et al. (2007). Erratum: Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (Journal of Cell Science vol. 120 (330-339)). nameOfConference

  
  

  DOI: 10.1242/jcs.03421

  
  

  QMRO: qmroHref
• Teh MT, Blaydon D, Ghali LR et al. (2007). Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. nameOfConference

  
  

  DOI: 10.1242/jcs.03329

  
  

  QMRO: qmroHref
• Pettersson F, Morris AP, Derwent PS et al. (2007). GOLDsurfer2: A comprehensive tool for the analysis and visualization of whole genome association studies. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Barnes MR (2007). Gaining insight into human population- specific selection pressure. nameOfConference

  
  

  DOI: 10.1201/9781420008876

  
  

  QMRO: qmroHref
• Philpott MP, Kelsell DP, Leigh IM et al. (2007). Role for WNT16B in Human Epidermal Keratinocyte Proliferation and Differentiation. nameOfConference

  
  

  DOI: 10.1242/jcs.03329

  
  

  QMRO: qmroHref
• Barnes MR, Deharo S, Grocock RJ et al. (2007). The micro RNA target paradigm: a fundamental and polymorphic control layer of cellular expression. nameOfConference

  
  

  DOI: 10.1517/14712598.7.9.1387

  
  

  QMRO: qmroHref
• Barnes MR (2006). Navigating the HapMap.. nameOfConference

  
  

  DOI: 10.1093/bib/bbl021

  
  

  QMRO: qmroHref
• Barnes MR, Holbrook J, Feild JA et al. (2006). Risk in drug trials. nameOfConference

  
  

  DOI: 10.1016/S0140-6736(06)69882-6

  
  

  QMRO: qmroHref
• Common JEA, Bitner-Glindzicz M, O'Toole EA et al. (2005). Specific loss of connexin 26 expression in ductal sweat gland epithelium associated with the deletion mutation del(GJB6-D13S1830). nameOfConference

  
  

  DOI: 10.1111/j.1365-2230.2005.01878.x

  
  

  QMRO: qmroHref
• Prabhakar U, Conway TM, Murdock P et al. (2005). Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects. nameOfConference

  
  

  DOI: 10.1089/dna.2005.24.410

  
  

  QMRO: qmroHref
• Scott BB, Zaratin PF, Clarke GD et al. (2004). C20orf9-003 (ACI-1), a gene localized on chromosome 20q13.12 encoding for a 49 kD cytoplasmic protein with a putative nucleotide binding site. nameOfConference

  
  

  DOI: 10.1080/1042517032000160200

  
  

  QMRO: qmroHref
• Barnes MR, Gray IC (2003). Concluding Remarks: Final Thoughts and Future Trends. nameOfConference

  
  

  DOI: 10.1002/0470867302.ch17

  
  

  QMRO: qmroHref
• Barnes MR (2003). Genetic Studies from Genomic Sequence. nameOfConference

  
  

  DOI: 10.1002/0470867302.ch9

  
  

  QMRO: qmroHref
• Barnes MR (2003). Genetic and Physical Map Resources – An Integrated View. nameOfConference

  
  

  DOI: 10.1002/0470867302.ch7

  
  

  QMRO: qmroHref
• Barnes MR (2003). Human Genetic Variation: Databases and Concepts. nameOfConference

  
  

  DOI: 10.1002/0470867302.ch3

  
  

  QMRO: qmroHref
• Barnes MR, Southan C (2003). Internet Resources for the Geneticist. nameOfConference

  
  

  DOI: 10.1002/0470867302.ch2

  
  

  QMRO: qmroHref
• Barnes MR, Gray IC (2003). Introduction: The Role of Genetic Bioinformatics. nameOfConference

  
  

  DOI: 10.1002/0470867302.ch1

  
  

  QMRO: qmroHref
• Barnes MR (2003). Predictive Functional Analysis of Polymorphisms: An Overview. nameOfConference

  
  

  DOI: 10.1002/0470867302.ch12

  
  

  QMRO: qmroHref
• Hosking LK, Boyd PR, Xu CF et al. (2002). Linkage disequilibrium mapping identifies a 390 kb region associated with CYP2D6 poor drug metabolising activity.. nameOfConference

  
  

  DOI: 10.1038/sj.tpj.6500096

  
  

  QMRO: qmroHref
• Barnes MR (2002). Psychiatric genetics in silico:: databases and tools for psychiatric geneticists. nameOfConference

  
  

  DOI: 10.1097/00041444-200206000-00003

  
  

  QMRO: qmroHref
• Dow D, Devitt PJ, Candlin A et al. (2002). SNP Locator - A bioinformatics tool for determining the distance between SNPs as an aid to linkage disequilibrium mapping.. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Barnes MR (2002). SNP and mutation data on the Web - hidden treasures for uncovering.. nameOfConference

  
  

  DOI: 10.1002/cfg.131

  
  

  QMRO: qmroHref
• McGinnis RE, Fox H, Yates P et al. (2001). Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland. nameOfConference

  
  

  DOI: 10.1038/88839

  
  

  QMRO: qmroHref
• Sims MA, Field SD, Barnes MR et al. (2000). Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51. nameOfConference

  
  

  DOI: 10.1159/000015631

  
  

  QMRO: qmroHref
• James IE, Kumar S, Barnes MR et al. (2000). FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis. nameOfConference

  
  

  DOI: 10.1053/joca.1999.0321

  
  

  QMRO: qmroHref
• Fear MW, Kelsell DP, Spurr NK et al. (2000). Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues. nameOfConference

  
  

  DOI: 10.1006/bbrc.2000.3852

  
  

  QMRO: qmroHref
• Wilgoss A, Leigh IM, Barnes MR et al. (1999). Identification of a novel mutation R42P in the gap junction protein beta-3 associated with autosomal dominant erythrokeratoderma variabilis.. nameOfConference

  
  

  DOI: 10.1046/j.1523-1747.1999.00792.x

  
  

  QMRO: qmroHref
• Barnes MR, Li Z (1999). Get practical! Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins edited by Andreas D. Baxevanis and B. F. Francis Ouellette. nameOfConference

  
  

  DOI: 10.1016/s0167-7799(99)01327-x

  
  

  QMRO: qmroHref
• Barnes MR, Russell RB (1999). A lipid-binding domain in Wnt: a case of mistaken identity?. nameOfConference

  
  

  DOI: 10.1016/S0960-9822(99)80465-5

  
  

  QMRO: qmroHref
• Valdes AM, Chamberlain JC, Bouzyk M et al. (1999). Genetics of osteoporosis: Association between ESR (11q12) and ERR1 (6q25) and bone mineral density and rate of change.. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Valdes AM, Bouzyk M, O'Brien E et al. (1999). Role of polymorphisms in parathyroid hormone receptor 1, transforming growth factor beta 1 and estrogen receptor in the genetics of osteoporosis.. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Hu E, Zhu Y, Fredrickson T et al. (1998). Tissue Restricted Expression of Two Human Frzbs in Preadipocytes and Pancreas Volume 247, Number 2 (1998), pages 287–293. nameOfConference

  
  

  DOI: 10.1006/bbrc.1998.9014

  
  

  QMRO: qmroHref
• Barnes MR, Duckworth DM, Beeley LJ (1998). Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family. nameOfConference

  
  

  DOI: 10.1016/S0165-6147(98)01246-2

  
  

  QMRO: qmroHref
• Duetz WA, Wind B, van Andel JG et al. (1998). Biodegradation kinetics of toluene, m-xylene, p-xylene and their intermediates through the upper TOL pathway in Pseudomonas putida (pWW0). nameOfConference

  
  

  DOI: 10.1099/00221287-144-6-1669

  
  

  QMRO: qmroHref
• Hu ED, Zhu Y, Fredrickson T et al. (1998). Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. nameOfConference

  
  

  DOI: 10.1006/bbrc.1998.8784

  
  

  QMRO: qmroHref
• Barnes MR, Duetz WA, Williams PA (1997). A 3-(3-hydroxyphenyl)propionic acid catabolic pathway in Rhodococcus globerulus PWD1: Cloning and characterization of the hpp operon. nameOfConference

  
  

  DOI: 10.1128/jb.179.19.6145-6153.1997

  
  

  QMRO: qmroHref

Collaborators

Internal

• Prof Mark Caulfield (WHRI)
• Prof Costantino Pitzalis (WHRI)
• Prof Leo Dunkel (WHRI)
• Prof Patricia Munroe (WHRI)
• Prof David Kelsell (Blizard)
• Prof Amrita Ahluwalia (WHRI)
• Prof Karim Brohi (Blizard)
• Prof David Van Heel (Blizard)
• Prof Silvia Marino (Blizard)
• Prof Sussan Nourshagh (WHRI)
• Prof Rupert Pearse (WHRI)
• Prof Steffen Petersen (WHRI)
• Prof Adam Timmis (WHRI)
• Dr Michael O'Dwyer (WHRI)
• Dr Myles Lewis (WHRI)

External

• Prof Nick Reynolds (Newcastle)
• Prof John Issacs (Newcastle)
• Prof Christopher Griffiths (Manchester)
• Prof Ann Morgan (Leeds)
• Prof Folkert Asselbergs (UCL)
• Dr Brendan Keating (UPENN)
• Prof Jo Knight (Lancaster)
• Dr Michael Weale (KCL)
• Dr Gerome Breen (Institute of Psychiatry, KCL)
• Prof Gerhard Ecker (University of Vienna)